persistent

By Targets:	Androgen Receptor (1) Antibiotic (1) Apoptosis (1) Bacterial (2) Bcl-2 Family (1) Biochemical Assay Reagents (1) Drug Metabolite (1) Epigenetic Reader Domain (1) Estrogen Receptor/ERR (2) Eukaryotic Initiation Factor (eIF) (1) Histone Methyltransferase (1) iGluR (1) Liposome (1) PPAR (2) Sodium Channel (4) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (2) Endocrinology (1) Infection (2) Inflammation/Immunology (4) Metabolic Disease (2) Neurological Disease (5)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-121212

Icosabutate	Others	Metabolic Disease Inflammation/Immunology
Icosabutate, an orally active ω-3 polyunsaturated fatty acid, is an aeicosapentaenoic acid (EPA) derivative. Icosabutate overcomes the drawbacks of unmodified EPA for liver targeting and improves insulin sensitivity, hepatic inflammation and fibrosis . Icosabutate is well tolerated, and efficacious in lowering non-high-density lipoprotein cholesterol (non-HDL-C) levels in persistent hypertriglyceridemia .

HY-W099689

3-Octanol

Others Others

3-Octanol is a fragrance ingredient. 3-octanol not to be persistent, bioaccumulative, and toxic .

3-Octanol	Others	Others
3-Octanol is a fragrance ingredient. 3-octanol not to be persistent, bioaccumulative, and toxic .

HY-132234

M-1211	Epigenetic Reader Domain	Cancer
M‑1121 is a covalent and orally active inhibitor of the menin-MLL interaction capable of achieving complete and persistent tumor regression .

HY-148792

Relutrigine PRAX-562	Sodium Channel	Neurological Disease
Relutrigine (PRAX-562) is an orally active inhibitor of persistent sodium channel. Relutrigine potently and preferentially inhibits persistent I_Na induced by ATX-II (Nav 1.5 activator) or the SCN8A mutation N1768D with IC₅₀ values of 141 nM and 75 nM, respectively. Relutrigine exhibits potent use-dependent block and reduces neuronal intrinsic excitability. Relutrigine has effective anticonvulsant activity .

HY-144007

Chol-PEG

Liposome Others

Chol-PEG is a nonionic surfactant vesicles and can be used for a blood-persistent drug delivery system .

Chol-PEG	Liposome	Others
Chol-PEG is a nonionic surfactant vesicles and can be used for a blood-persistent drug delivery system .

HY-132922

EEDi-5273 APG-5918	Histone Methyltransferase	Cancer
EEDi-5273 is an exceptionally potent and orally efficacious EED inhibitor (IC₅₀ = 0.2 nM) capable of achieving complete and persistent tumor regression.

HY-108569

nTZDpa	Antibiotic Bacterial PPAR	Infection
nTZDpa is an antibiotic. nTZDpa is a PPARG partial agonist. nTZDpa has antibacterial activity. nTZDpa is effective against growing and persistent Staphylococcus aureus by lipid bilayer disruption .

HY-B1986

p,p'-DDE 4,4'-DDE; p,p'-Dichlorodiphenyldichloroethylene
p,p'-DDE (4,4'-DDE), a major metabolite of persistent dichlorodiphenyltrichloroethane (DDT), is a potent androgen receptor antagonist, with an IC₅₀ of 5 μM and a K_i of 3.5 μM .

HY-18689

SYM2206

iGluR Neurological Disease

SYM2206 is a potent and non-competitive AMPA receptor antagonist, with an IC₅₀ of 1.6 μM. SYM2206 blocks Na_v1.6-mediated persistent currents .

SYM2206	iGluR	Neurological Disease
SYM2206 is a potent and non-competitive AMPA receptor antagonist, with an IC₅₀ of 1.6 μM. SYM2206 blocks Na_v1.6-mediated persistent currents .

HY-107335

Aplodan Creatinol O-phosphate; Creatinol phosphate; Creatinolfosfate	Others	Cardiovascular Disease
Aplodan is an antiischemic and antiarrhythmic agent. Aplodan has a protective action on cell membrane. Aplodan has the potential for the research of ischemic heart or ischemic heart disease with persistent ventricular premature beats (VPB) .

HY-136441

Triclosan-methyl	Bacterial	Infection
Triclosan-methyl is a transformation product of triclosan. Triclosan is a bactericide in personal care products such as toothpaste, shampoos, and soaps. Triclosan is also a stabilizing agent in a multitude of detergents and cosmetics .

HY-12825

BHPI	Estrogen Receptor/ERR	Cancer
BHPI is a potent inhibitor of nuclear estrogen–ERα-regulated gene expression; elicits sustained ERα-dependent activation of the endoplasmic reticulum (EnR) stress sensor, the unfolded protein response (UPR), and persistent inhibition of protein synthesis.

HY-131122S

4-Nonylphenol-D5 4-n-Nonylphenol-2,3,5,6-d4,OD	Estrogen Receptor/ERR	Others
4-Nonylphenol-d₅ is the deuterium labeled 4-Nonylphenol. 4-Nonylphenol, a major degradation product of Nonylphenol ethoxylates (NPEOs), is a persistent organic pollutant with endocrine-disrupting properties and exerts estrogenic activity[1].

HY-19463A

F15845	Sodium Channel	Cardiovascular Disease
F 15845 is a highly effective persistent sodium current blocker. F 15845 also is a cardioprotective agent, has anti-ischemic activity and exerts short- and long-term cardioprotection after myocardial infarction. F 15845 can be used for the research of myocardium functional impairment .

HY-129683

AM3102	PPAR	Metabolic Disease
AM3102 is an oleoylethanolamide (OEA) analog. AM3102 is an endogenous high-affinity PPAR-alpha agonist. AM3102 resists enzymatic hydrolysis, activates PPAR-alpha with high potency in vitro, and persistently reduces feeding when administered in vivo either parenterally or orally .

HY-P1952

µ-Conotoxin-CnIIIC	Sodium Channel	Inflammation/Immunology
μ-Conotoxin-CnIIIC is a 22-residue conopeptide that can be isolated from Conus consors. μ-Conotoxin-CnIIIC is a potent and persistent blocker of Na_V1.4 channel. μ-Conotoxin-CnIIIC has analgesic, anaesthetic and myorelaxant properties .

HY-B1986S

p,p'-DDE-d8 4,4'-DDE-d₈; p,p'-Dichlorodiphenyldichloroethylene-d₈	Androgen Receptor Drug Metabolite	Endocrinology
p,p'-DDE-d₈ is the deuterium labeled p,p'-DDE[1]. p,p'-DDE (4,4'-DDE), a major metabolite of persistent dichlorodiphenyltrichloroethane (DDT), is a potent androgen receptor antagonist, with an IC50 of 5 μM and a Ki of 3.5 μM[2].

HY-P5172

MitTx-alpha	Sodium Channel	Neurological Disease
MitTx-alpha is a subunit of MitTx. MitTx is a potent, persistent, and selective agonist for acid-sensing ion channels (ASICs). MitTx is highly selective for the ASIC1 subtype at neutral pH; under more acidic conditions (pH<6.5), MitTx massively potentiates (>100-fold) proton-evoked activation of ASIC2a channels .

HY-12495A

ISRIB 5 Publications Verification	Biochemical Assay Reagents Eukaryotic Initiation Factor (eIF)	Neurological Disease
ISRIB is a brain-penetrant inhibitor of integrated stress response (ISR). Persistent activation of the ISR has been linked to the development of several neurological disorders as ISR represses translation through inhibiting eIF2B. ISRIB inhibits the ISR by promoting the nucleotide exchange activity of eIF2B and recovering the translation, and thus can be used for neurological disorders research .

HY-121337

Flurochloridone R-40244	Apoptosis Bcl-2 Family	Others
Flurochloridone (R-40244) is a selective preemergence and persistent herbicide. Flurochloridone induces endoplasmic reticulum (ER) stress and activated unfolded protein response (UPR) signaling pathways. Flurochloridone impairs cell viability and induces cytotoxicity and apoptosis mediated by ER stress via activating eIF2α-ATF4/ATF6-CHOP-Bim/Bax signaling pathways in TM4 cells .

HY-153808

Complete Freund's adjuvant (CFA)	Toll-like Receptor (TLR)	Inflammation/Immunology
Complete Freund's adjuvant (CFA) is an immunoadjuvant emulsified with antigen by its discoverer Jules T. Freund to enhance an animal's immune response to an antigen. Complete Freund's adjuvant (CFA) is also an inducer of the Th1 immune response and a ligand of TLRs. Complete Freund's adjuvant (CFA) contains heat-killed inactive tuberculosis bacilli and consists of a paraffin oil-in-water emulsion. Complete Freund's adjuvant (CFA) stimulates a strong and durable immune response and can be used to induce persistent inflammatory pain models in mice, experimental autoimmune myocarditis (EAM) models, and more. Incomplete Freund's adjuvant (IFA) (HY-153808A) is another type of Freund's Adjuvant that stimulates a weaker immune response .

Cat. No.	Product Name	Type

HY-12495A

ISRIB 5 Publications Verification	Biochemical Assay Reagents
ISRIB is a brain-penetrant inhibitor of integrated stress response (ISR). Persistent activation of the ISR has been linked to the development of several neurological disorders as ISR represses translation through inhibiting eIF2B. ISRIB inhibits the ISR by promoting the nucleotide exchange activity of eIF2B and recovering the translation, and thus can be used for neurological disorders research .

ISRIB

5 Publications Verification

Biochemical Assay Reagents

ISRIB is a brain-penetrant inhibitor of integrated stress response (ISR). Persistent activation of the ISR has been linked to the development of several neurological disorders as ISR represses translation through inhibiting eIF2B. ISRIB inhibits the ISR by promoting the nucleotide exchange activity of eIF2B and recovering the translation, and thus can be used for neurological disorders research .

HY-144007

Chol-PEG

Drug Delivery

Chol-PEG is a nonionic surfactant vesicles and can be used for a blood-persistent drug delivery system .

Chol-PEG	Drug Delivery
Chol-PEG is a nonionic surfactant vesicles and can be used for a blood-persistent drug delivery system .

Cat. No.	Product Name	Target	Research Area

HY-P5914

Wasabi Receptor Toxin WaTx	Peptides	Neurological Disease
Wasabi Receptor Toxin (WaTx) active TRPA1 by prolonged channel openings and decreased Ca ²⁺ permeability. Wasabi Receptor Toxin can be used in the research of acute and persistent pain .

HY-P1952

µ-Conotoxin-CnIIIC	Sodium Channel	Inflammation/Immunology
μ-Conotoxin-CnIIIC is a 22-residue conopeptide that can be isolated from Conus consors. μ-Conotoxin-CnIIIC is a potent and persistent blocker of Na_V1.4 channel. μ-Conotoxin-CnIIIC has analgesic, anaesthetic and myorelaxant properties .

HY-P5172

MitTx-alpha	Sodium Channel	Neurological Disease
MitTx-alpha is a subunit of MitTx. MitTx is a potent, persistent, and selective agonist for acid-sensing ion channels (ASICs). MitTx is highly selective for the ASIC1 subtype at neutral pH; under more acidic conditions (pH<6.5), MitTx massively potentiates (>100-fold) proton-evoked activation of ASIC2a channels .

Cat. No.	Product Name	Target	Research Area

HY-P9950

Omalizumab 1 Publications Verification Olizumab; rhuMab-E25	Inhibitory Antibodies	Inflammation/Immunology Cancer
Omalizumab is a recombinant, humanized, monoclonal antibody against human immunoglobulin E (IgE) with a K_D of 0.393 nM. Omalizumab binds to the human FcγRIIb receptors with a K_D of 6.37 uM. Omalizumab has the potential for persistent allergic asthma research .

Cat. No.	Product Name	Chemical Structure

HY-131122S

4-Nonylphenol-D5
4-Nonylphenol-d₅ is the deuterium labeled 4-Nonylphenol. 4-Nonylphenol, a major degradation product of Nonylphenol ethoxylates (NPEOs), is a persistent organic pollutant with endocrine-disrupting properties and exerts estrogenic activity[1].

HY-B1986S

p,p'-DDE-d8
p,p'-DDE-d₈ is the deuterium labeled p,p'-DDE[1]. p,p'-DDE (4,4'-DDE), a major metabolite of persistent dichlorodiphenyltrichloroethane (DDT), is a potent androgen receptor antagonist, with an IC50 of 5 μM and a Ki of 3.5 μM[2].

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