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Results for "

probe+design

" in MedChemExpress (MCE) Product Catalog:

13

Inhibitors & Agonists

4

Fluorescent Dyes

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-134418
    NOTA

    		Radionuclide-Drug Conjugates (RDCs) Cardiovascular Disease Cancer
    NOTA is a bifunctional chelate which acts as the framework to construct PET imaging tools. NOTA also can be used for probe design and signal amplification via the multivalent effect. NOTA can be used in multiple myeloma, breast cancer, lymphoma and myocardial infarction research .
    NOTA
  • HY-177554
    KB05yne

    		Biochemical Assay Reagents Cancer
    KB05yne is a site-selective, alkyne-functionalized electrophilic "probe" fragment probe designed for covalent ligand discovery, with preferential reactivity toward specific cysteine residues in proteins. KB05yne strongly labels wild-type target proteins (e.g., CDKN2AIP, HPCAL1) but does not label their cysteine-to-alanine mutants, confirming site-specific cysteine reactivity. KB05yne can be used for the discovery and optimization of site-specific covalent ligands, and is applicable to proteins with diverse structures and functions, especially in studies targeting cysteine residues in cancer-related or difficult-to-purify proteins .
    KB05yne
  • HY-135235
    Cysteine thiol probe
    1 Publications Verification

    		 Fluorescent Dye Others
    Cysteine Thiol Probe is a thiol-based probe designed to label electrophilic natural products. Cysteine Thiol Probe possesses each of the characteristics of an ideal pharmacophore probe, and has a chromophore. Cysteine Thiol Probe is capable of engaging enone-, β-lactam-, and β-lactone-based electrophilic metabolites .
    Cysteine thiol probe
  • HY-150175
    HKSOX-1

    		Fluorescent Dye Inflammation/Immunology
    HKSOX-1 and its derivatives (HKSOX-1r and HKSOX-1m) are novel fluorescent probes designed for highly sensitive and selective detection of the superoxide anion radical (O2 •−) in cellular environments. These probes utilize an aryl trifluoromethanesulfonate group that undergoes O2 •−-mediated cleavage, releasing a free phenol and emitting fluorescence. They demonstrate excellent specificity and sensitivity across various pH ranges, withstand interference from strong oxidants and reductants typical in cellular contexts. HKSOX-1r, optimized for cellular retention, has been effectively employed in diverse assays including confocal imaging, flow cytometry, and zebrafish embryo studies, highlighting its utility in investigating O2 •− roles in inflammation, mitochondrial stress, and other physiological processes .
    HKSOX-1
  • HY-164785
    TCO-PEG5-C2-Mal

    		Drug Intermediate Others
    TCO-PEG5-maleimide is a PEG linker with TCO and maleimide groups, specifically enabling tetrazine click chemistry and thiol conjugation for bioconjugation, probe design, and drug delivery.
    TCO-PEG5-C2-Mal
  • HY-D2324
    EE-Flipper 33

    		Fluorescent Dye Others
    EE-Flipper 33 is a Flipper probe designed to evaluate the mechanism of early endocytosis. EE-Flipper has a pKa value of 10.6 and is capable of tracking approximately 70% of early endosomes (EE) in live cells. Furthermore, EE-Flipper 33 can also label the Golgi apparatus in live cells with an internal pH ranging from 6.0 to 6.7 .
    EE-Flipper 33
  • HY-134418R
    NOTA (Standard)

    		Radionuclide-Drug Conjugates (RDCs) Reference Standards Cardiovascular Disease Cancer
    NOTA (Standard) is the analytical standard of NOTA. This product is intended for research and analytical applications. NOTA is a bifunctional chelate which acts as the framework to construct PET imaging tools. NOTA also can be used for probe design and signal amplification via the multivalent effect. NOTA can be used in multiple myeloma, breast cancer, lymphoma and myocardial infarction research .
    NOTA (Standard)
  • HY-W1119950
    3'-NH-Tr-2',3'-DMF-ddA- 5'-CE-Phosphoramidite

    		Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Others
    3'-NH-Tr-2',3'-DMF-ddA-5'-CE-Phosphoramidite is an adenine nucleotide monomer precursor used in solid-phase synthesis of oligonucleotides, particularly modified oligonucleotides, such as those with DNA chain end modifications. 3'-NH-Tr-2',3'-DMF-ddA-5'-CE-Phosphoramidite, with trityl (Tr), cyanoethyl (CE), and dimethylformamidine (DMF) protecting groups, is a ddNTP adenosine nucleoside useful in applications such as solid-phase oligonucleotide synthesis, probe design, and chain-termination sequencing .
    3'-NH-Tr-2',3'-DMF-ddA- 5'-CE-Phosphoramidite
  • HY-173390
    BCN-E-BCN

    		Drug Intermediate Biochemical Assay Reagents Others
    BCN-E-BCN is a strained cycloalkyne-based probe designed for detecting protein sulfenylation, the primary intermediate in protein oxidation. This structurally constrained cycloalkyne compound specifically recognizes sulfenic acid groups formed during thiol oxidation, while remaining completely unreactive toward other oxidative states (such as free thiols, sulfinic, or sulfonic acid groups). Researchers can leverage its efficient conjugation with azide-bearing tags through copper-free click chemistry to amplify detection signals. Compared to conventional detection methods, BCN-E-BCN demonstrates superior reaction kinetics and enhanced sensitivity. With these advantages, BCN-E-BCN shows great promise as an effective tool for protein oxidation research .
    BCN-E-BCN
  • HY-181455
    rel-FTY720 phenoxy-biotin hydrochloride

    		Drug Derivative Others
    rel-FTY720 phenoxy-biotin hydrochloride is a chemical probe designed based on the structure of Fingolimod (HY-12005), which incorporates a phenoxy group capable of specific click chemistry reactions and is conjugated with a biotin tag .
    rel-FTY720 phenoxy-biotin hydrochloride
  • HY-D3143
    QM-B-CF

    		Fluorescent Dye Cancer
    QM-B-CF is a sequential dual-lock chemiluminescent/fluorescent dual-mode probe designed for the specific detection of H2O2, and it can produce enhanced chemiluminescence upon photoirradiation. QM-B-CF generates chemiluminescent signals only under the conditions of H2O2 and light exposure in vitro, in cancer cells, and in tumor-bearing nude mice (Ex/Em = 514 nm/600 nm) .
    QM-B-CF
  • HY-158616
    4-Methyl-7-(2-nitrophenoxy)-2H-chromen-2-one

    		Fluorescent Dye Others
    4-Methyl-7-(2-nitrophenoxy)-2H-chromen-2-one (compound 2f) is a selenol fluorescent probe designed based on a nucleophilic aromatic substitution mechanism. It can selectively recognize selenols in neutral aqueous solution without significant interference from biological thiols, amines or alcohols. It can be used to quantify the selenium content in selenoenzymes and to image the activity of endogenous selenols in living cells.
    4-Methyl-7-(2-nitrophenoxy)-2H-chromen-2-one
  • HY-D3141
    DR probe

    		Cancer
    DR probe is a "dual-key-and-lock" fluorescent probe designed based on the Resorufin (HY-123533) scaffold (Ex/Em = 647 nm/663-738 nm). DR probe can be sequentially activated by hydrogen peroxide to form the intermediate SR, which acts as a tyrosinase substrate to trigger a fluorescence turn-on signal. DR probe can distinguish normal melanocytes from melanoma cells. DR probe supports cell imaging and can be applied to mouse melanoma models to achieve melanoma diagnosis with higher accuracy and lower false-positive rates. DR probe is applicable to relevant research on melanoma .
    DR probe

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