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substituent

" in MedChemExpress (MCE) Product Catalog:

15

Inhibitors & Agonists

1

Fluorescent Dye

1

Biochemical Assay Reagents

1

Natural
Products

1

Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-Y0694
    2',4'-Dihydroxyacetophenone

    Resacetophenone; 1-​(2,​4-​Dihydroxyphenyl)​ethanone

    		 Endogenous Metabolite Others
    2',4'-Dihydroxyacetophenone (Resacetophenone) is acetophenone carrying hydroxy substituents at positions 2' and 4'. A plant metabolite.
    2',4'-Dihydroxyacetophenone
  • HY-W010865
    N-Benzylquinine chloride

    		Biochemical Assay Reagents Others
    N-Benzylquinine (chloride) is an organic compound. N-Benzylquinine is a derivative of quinoxalines with benzyl substituents. N-Benzylquinine salts are beneficial for the production of tetrahydrofuran trans epoxides .
    N-Benzylquinine chloride
  • HY-W006416
    1,2,3,4-Tetramethylbenzene

    		Others Others
    1,2,3,4-Tetramethylbenzene consists of a benzene ring with four methyl groups (-CH3) as a substituent. 1,2,3,4-Tetramethylbenzene is a specialty product for biochemistry research .
    1,2,3,4-Tetramethylbenzene
  • HY-130219
    18-HETE

    		Endogenous Metabolite Others
    18-HETE (compound 3) is a monooxygenase metabolite of cytochrome P450 (CYP450).18- HETE consists of arachidonic acid bearing a hydroxy substituent at position 18 .
    18-HETE
  • HY-161249
    Vanin-1-IN-4

    		Others Inflammation/Immunology
    Vanin-1-IN-4 (compound (S)-1) is vanin-1 inhibitor with a chiral methyl substituent, with profils as potent drug-candidate but exist as an amorphous solid .
    Vanin-1-IN-4
  • HY-W075603
    2,6-Diiodo-BODIPY 493/503

    2,6-Diiodo-Pyrromethene 546; 2,6-Diiodo-BDP 493/503 lipid stain

    		 Fluorescent Dye Others
    2,6-Diiodo-BODIPY 493/503 is an F-Bodipy fluorescent dye with diiodo substitution at the (pyrrole) 2,6 position. 2,6-Diiodo-BODIPY 493/503 has a pyrrole iodine substituent that turns it red .
    2,6-Diiodo-BODIPY 493/503
  • HY-B1594
    Carbromal

    Adalin; Adisomnol; Bromacetocarbamide

    		 Others Neurological Disease
    Carbromal (Adalin; Adisomnol) is a sedative with centrally depressant effects .
    Carbromal
  • HY-B0323
    Sulfisoxazole
    2 Publications Verification

    Sulfafurazole

    		 Endothelin Receptor Bacterial Antibiotic Infection Endocrinology Cancer
    Sulfisoxazole (Sulfafurazole) is an orally active endothelin receptor antagonist with IC50 values of 0.60 μM and 22 μM against endothelin receptor A and endothelin receptor B, respectively. Sulfisoxazole is a sulfonamide antibacterial agent with an oxazole substituent. Sulfisoxazole inhibits breast cancer exosome release by targeting endothelin receptor A .
    Sulfisoxazole
  • HY-W089785
    Methyl α-D-galactopyranoside monohydrate

    		Others Others
    Methyl α-D-galactopyranoside monohydrate is an alpha-D-galactoside having a methyl substituent at the anomeric position. Methyl α-D-galactopyranoside inhibits debaryomyces hansenii UFV-1 extracellular and intracellular α-galactosidases with Ki values of 0.82 and 1.12 mM, respectively .
    Methyl α-D-galactopyranoside monohydrate
  • HY-B0323A
    Sulfisoxazole diethanolamine

    Sulfafurazole diethanolamine

    		 Endothelin Receptor Antibiotic Bacterial Infection Endocrinology Cancer
    Sulfisoxazole (Sulfafurazole) diethanolamine is an endothelin receptor antagonist with IC50 values of 0.60 μM and 22 μM against endothelin receptor A and endothelin receptor B, respectively. Sulfisoxazole diethanolamine is a sulfonamide antibacterial with an oxazole substituent. Sulfisoxazole diethanolamine inhibits breast cancer exosome release by targeting endothelin receptor A .
    Sulfisoxazole diethanolamine
  • HY-136563
    RA375

    		Proteasome Apoptosis Reactive Oxygen Species Cancer
    RA375 is a RPN13 (26S proteasome regulatory subunit) inhibitor. RA375 activates UPR signaling, ROS production and apoptosis. RA375 exhibits ten-fold greater activity against cancer lines than RA190, reflecting its nitro ring substituents and the addition of a chloroacetamide warhead .
    RA375
  • HY-12210
    (S)-BI-1001

    		HIV Integrase Infection
    (S)-BI-1001 (Compound 11) is an active S-enantiomer of BI-1001. (S)-BI-1001 exhibits antiviral potency against HIV-1 integrase with an IC50 of 28 nM, an EC50 of 450 nM and a Kd of 4.7 μM .
    (S)-BI-1001
  • HY-157778
    MK-7845

    		SARS-CoV Infection
    MK-7845 is a reversible covalent SARS-CoV-2 3CL protease inhibitor with an IC50 of 8.7 nM .
    MK-7845
  • HY-134813
    MRTX1133
    3 Publications Verification

    		 Ras Cancer
    MRTX1133 is a noncovalent, potent, and selective KRAS G12D inhibitor. MRTX1133 optimally fills the switch II pocket and extends three substituents to favorably interact with the protein, resulting in an estimated KD against KRAS G12D of 0.2 pM. MRTX1133 prevents SOS1-catalyzed nucleotide exchange and/or formation of the KRAS G12D/GTP/RAF1 complex, thereby inhibiting mutant KRAS-dependent signal transduction. MRTX1133 selectively inhibits KRAS G12D mutant, but not KRAS wild-type, tumor cells. MRTX1133 has single digit nanomolar activity in cellular assays and marked in vivo efficacy in tumor models harboring KRAS G12D mutations .
    MRTX1133
  • HY-151754
    DACN(Tos2,6-OH)

    		ADC Linker Others
    DACN(Tos2,6-OH) is a click chemistry reagent containing an Azide. The alkyne moiety within the ring has a unique bent structure and high reactivity toward cycloaddition reactions. The reactivity of an alkyne heavily depends on the electronic and steric characteristics of the substituents as well as structural strain. In comparison to nonbent acyclic alkynes, cyclononyne alkynes show remarkably high reactivity. Such strain-promoted azide-alkyne cycloadditions (SPAAC) using cycloalkynes have served for reliable molecular conjugation in a broad range of fields. The nitrogens are used as connection points for a variety of functional units. In comparison to cyclooctynes, DACNs possess high thermal and chemical stability along with comparable click reactivity . DACN(Tos2,6-OH) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    DACN(Tos2,6-OH)

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