1. Metabolic Enzyme/Protease
    Apoptosis
    Immunology/Inflammation
    NF-κB
  2. Proteasome
    Apoptosis
    Reactive Oxygen Species
  3. RA375

RA375 

Cat. No.: HY-136563
Handling Instructions

RA375 is a RPN13 (26S proteasome regulatory subunit) inhibitor. RA375 activates UPR signaling, ROS production and apoptosis. RA375 exhibits ten-fold greater activity against cancer lines than RA190, reflecting its nitro ring substituents and the addition of a chloroacetamide warhead.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

RA375 Chemical Structure

RA375 Chemical Structure

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Description

RA375 is a RPN13 (26S proteasome regulatory subunit) inhibitor. RA375 activates UPR signaling, ROS production and apoptosis. RA375 exhibits ten-fold greater activity against cancer lines than RA190, reflecting its nitro ring substituents and the addition of a chloroacetamide warhead[1].

In Vivo

RA375 (10 mg/kg, ip) inhibits proteasome function and reduces ovarian tumor burden in mice[1].

Animal Model: RA375 (10 mg/kg, ip) inhibits proteasome function and reduces ovarian tumor burden in mice[1].
Dosage: 10 mg/kg.
Administration: IP for a 5 days on, 2 days off cycle for two weeks.
Result: Reduced ovarian tumor burden in mice.
Animal Model: Female Balb/c mice[1].
Dosage: 5, 10, 20, 40, 60, 100 mg/kg (Pharmacological Analysis).
Administration: IP single dose.
Result: The dose of 40 mg/kg on alternate days for two weeks produced no observable toxicities or weight loss.
Molecular Weight

589.00

Formula

C₃₀H₂₅ClN₄O₇

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (212.22 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6978 mL 8.4890 mL 16.9779 mL
5 mM 0.3396 mL 1.6978 mL 3.3956 mL
10 mM 0.1698 mL 0.8489 mL 1.6978 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

RA375RA 375RA-375ProteasomeApoptosisReactive Oxygen Species26SproteasomeovariantumorInhibitorinhibitorinhibit

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