2649154-57-2
Chemical Structure
RA375
- CAS No.: 2649154-57-2
- Formula:C30H25ClN4O7
- Molecular Weight:589.00
IUPAC Name: N-((S)-1-(3,5-bis((E)-4-nitrobenzylidene)-4-oxopiperidin-1-yl)-1-oxo-3-phenylpropan-2-yl)-2-chloroacetamide
InChIKey: REFAVUFYPFWJGH-SWAPHQFDSA-N
SMILES: O=C([C@@H](NC(CCl)=O)CC1=CC=CC=C1)N(C/C(C/2=O)=C\C3=CC=C([N+]([O-])=O)C=C3)CC2=C/C4=CC=C([N+]([O-])=O)C=C4
Biological Activity: RA375 is a RPN13 (26S proteasome regulatory subunit) inhibitor. RA375 activates UPR signaling, ROS production and apoptosis. RA375 exhibits ten-fold greater activity against cancer lines than RA190, reflecting its nitro ring substituents and the addition of a chloroacetamide warhead[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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RA375 | 99.87% | RA375 is a RPN13 (26S proteasome regulatory subunit) inhibitor. RA375 activates UPR signaling, ROS production and apoptosis. RA375 exhibits ten-fold greater activity against cancer lines than RA190, reflecting its nitro ring substituents and the addition of a chloroacetamide warhead. | ||||||||||||||||||||
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Keywords
