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Results for "

wee1+inhibitor

" in MedChemExpress (MCE) Product Catalog:
製品番号 製品名 Target 研究分野 構造式
  • HY-10993
    Adavosertib
    Maximum Cited Publications
    63 Publications Verification

    AZD1775; MK-1775

    		 Wee1 Cancer
    Adavosertib (AZD-1775; MK-1775) is a potent Wee1 inhibitor with an IC50 of 5.2 nM.
    Adavosertib
  • HY-132295
    Azenosertib
    4 Publications Verification

    ZN-c3

    		 Wee1 Cancer
    Azenosertib (ZN-c3) is a selective, orally active inhibitor for Wee1 inhibitor (IC50=3.9 nM). Azenosertib exhibits antitumor activity [1].
    Azenosertib
  • HY-147054
    Zedoresertib

    Debio 0123; wee1-IN-5

    		 Wee1 CDK Cancer
    Zedoresertib (Debio 0123) is a potent WEE1 inhibitor with an IC50 value of 0.8 nM. Zedoresertib inhibits phospho-CDC2. Zedoresertib abrogates the G2 check point, increasing sensitivity to DNA damaging agents in cancer cells. Zedoresertib can be used for researching anticancer [1].
    Zedoresertib
  • HY-13925
    PD0166285
    5+ Cited Publications

    		 Wee1 Apoptosis Cancer
    PD0166285, a substrate of P-gp, is a WEE1 inhibitor and a weak Myt1 inhibitor with IC50 values of 24 and 72 nM, respectively. PD0166285 exhibits an IC50 of 3.433 μM for Chk1 [1].
    PD0166285
  • HY-18961
    PD 407824

    		Checkpoint Kinase (Chk) Wee1 Inflammation/Immunology Cancer
    PD 407824 is a checkpoint kinase Chk1 and WEE1 inhibitor with IC50s of 47 and 97 nM, respectively. PD 407824 is a chemical BMP sensitizer and increases the sensitivity of cells to sub-threshold amounts of BMP4 [1] .
    PD 407824
  • HY-10993R
    Adavosertib (Standard)

    AZD1775 (Standard); MK-1775 (Standard)

    		 Reference Standards Wee1 Cancer
    Adavosertib (Standard) is the analytical standard of Adavosertib. This product is intended for research and analytical applications. Adavosertib (AZD-1775; MK-1775) is a potent Wee1 inhibitor with an IC50 of 5.2 nM.
    Adavosertib (Standard)
  • HY-161871
    WEE1-IN-8

    		Wee1 Cancer
    WEE1-IN-8 (Compound 55) is a selective WEE1 inhibitor, with an IC50 of 0.98 nM. WEE1-IN-8 (Compound 55) can be used for the research of Pancreatic cancer, Ovarian cancer, Colorectal cancer, Uterine serous carcinoma, etc [1].
    WEE1-IN-8
  • HY-161879
    WEE1-IN-9

    		Wee1 Cancer
    WEE1-IN-9 (Compound 1) is a Wee1 inhibitor that can be used in cancer research [1].
    WEE1-IN-9
  • HY-160530
    WEE1-IN-6

    		Wee1 Cancer
    WEE1-IN-6 (compound 110) is a orally active WEE1 inhibitor with an DC50 value of ≦ 100 nM. WEE1-IN-6 inhibits cell proliferation [1].
    WEE1-IN-6
  • HY-133702
    Aniline-piperazine-C3-NH-Boc

    		PROTAC Linkers Cancer
    Aniline-piperazine-C3-NH-Boc (Compound Int-3) is a PROTAC linker, and can be used for synthesis of Pomalidomide-C3-adavosertib (HY-133618) and AZD1775 (HY-10993) (a Wee1 inhibitor) [1].
    Aniline-piperazine-C3-NH-Boc
  • HY-178150
    WEE1-IN-14

    		Wee1 Cancer
    WEE1-IN-14 (Compound 14) is a selective WEE1 inhibitor (IC50: 0.5 nM in L-RB-FEP calculations, 1.0 nM in ADP-Glo kinase assay). Inhibition of Wee1 in cancer cells disrupts the G2-M checkpoint, removes the regulatory controls on the cell cycle, and leads to early onset of mitotic failure followed by apoptosis of tumor cells. Therefore, WEE1-IN-14 is a useful tool for studying cancer biology [1].
    WEE1-IN-14
  • HY-13925A
    PD0166285 dihydrochloride

    		Wee1 Apoptosis Cancer
    PD0166285 dihydrochloride, a substrate of P-gp, is a WEE1 inhibitor and a weak Myt1 inhibitor with IC50 values of 24 and 72 nM, respectively. PD0166285 dihydrochloride exhibits an IC50 of 3.433 μM for Chk1 [1].
    PD0166285 dihydrochloride
  • HY-108343R
    WEE1-IN-4 (Standard)

    		Reference Standards Wee1 Cancer
    WEE1-IN-4 (Standard) is the analytical standard of WEE1-IN-4 (HY-108343). This product is intended for research and analytical applications. WEE1-IN-4 (Compound 15) is a potent checkpoint Wee1 Kinase inhibitor with an IC50 of 0.011 μM. Wee1 inhibitors can abrogate the G2/M checkpoint [1].
    WEE1-IN-4 (Standard)

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