Shatavarin IV  (Synonyms: Asparanin B)

Shatavarin IV is a steroidal saponin, that can be isolated from the roots of Asparagus racemosus (Liliaceae). Shatavarin IV shows anticancer activity. Shatavarin IV elicits lifespan extension and alleviates Parkinsonism in Caenorhabditis elegans^[1].

Shatavarin IV (50 μM) reduces the accumulation of intracellular lipofuscin in C. elegans^[1].
Shatavarin IV (0-100 μM) reduces ROS level in C. elegans^[1].
Shatavarin IV (50 μM) significantly increases the mRNA expression of stress responsive genes in C. elegans, namely sod-1, sod-2, sod-3, gst-4, gst-7 and ctl-2^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

887.06

C₄₅H₇₄O₁₇

84633-34-1

Solid

White to off-white

C[C@@]12[C@]3([H])[C@](O[C@]4(CC[C@@H](CO4)C)[C@H]3C)([H])C[C@@]1([H])[C@@]5([H])[C@]([C@@]6([C@](C[C@H](CC6)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O[C@H]8[C@@H]([C@@H]([C@H]([C@@H](O8)C)O)O)O)O)O[C@@H]9O[C@@H]([C@H]([C@@H]([C@H]9O)O)O)CO)([H])CC5)C)([H])CC2

Room temperature in continental US; may vary elsewhere.

• [1]. Smita SS,et al. Shatavarin IV elicits lifespan extension and alleviates Parkinsonism in Caenorhabditis elegans. Free Radic Res. 2017 Dec;51(11-12):954-969.  [Content Brief]