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Soticlestat (Synonyms: TAK-935; OV935)

Cat. No.: HY-109123
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Soticlestat (TAK-935;OV935) is a potent, selective, orally active and first-in-class cholesterol 24-hydroxylase inhibitor. Soticlestat has the potential for epilepsy syndromes research.

For research use only. We do not sell to patients.

Soticlestat Chemical Structure

Soticlestat Chemical Structure

CAS No. : 1429505-03-2

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Description

Soticlestat (TAK-935;OV935) is a potent, selective, orally active and first-in-class cholesterol 24-hydroxylase inhibitor. Soticlestat has the potential for epilepsy syndromes research[1][2].

In Vitro

Cholesterol 24-hydroxylase (CH24H) is predominantly expressed in the brain, where it converts cholesterol into 24S-hydroxycholesterol (24HC) to adjust the homeostatic balance of brain cholesterol. CH24H is involved in over-activation of the glutamatergic pathway through modulation of the NMDA channel and that increased expression of CH24H can disrupt the reuptake of glutamate by astrocytes, resulting in epileptogenesis and neurotoxicity. Inhibition of CH24H by Soticlestat reduces the neuronal levels of 24HC and may improve excitatory/inhibitory balance of NMDA channel activity[2].

Molecular Weight

373.45

Formula

C₂₃H₂₃N₃O₂

CAS No.

1429505-03-2

SMILES

O=C(N1CCC(CC2=CC=CC=C2)(O)CC1)C3=C(C4=CC=NC=C4)N=CC=C3

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

SoticlestatTAK-935OV935TAK935TAK 935OV 935OV-935Others24-hydroxylasecholesterolfirst-in-classepilepsyantiepilepticNMDAInhibitorinhibitorinhibit

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