2. Metabolic Enzyme/Protease
  3. Cytochrome P450
  4. Soticlestat

Soticlestat  (Synonyms: TAK-935; OV935)

Cat. No.: HY-109123 Purity: 99.25%
COA Handling Instructions

Soticlestat (TAK-935; OV935) is a first-in-class, potent, selective, and orally active cholesterol 24-hydroxylase (CH24H) inhibitor. Soticlestat has the potential for epilepsy syndromes research.

For research use only. We do not sell to patients.

Soticlestat Chemical Structure

Soticlestat Chemical Structure

CAS No. : 1429505-03-2

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Solution
10 mM * 1 mL in DMSO USD 242 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 242 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 220 In-stock
Estimated Time of Arrival: December 31
10 mg USD 385 In-stock
Estimated Time of Arrival: December 31
25 mg USD 715 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1045 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1485 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Soticlestat (TAK-935; OV935) is a first-in-class, potent, selective, and orally active cholesterol 24-hydroxylase (CH24H) inhibitor. Soticlestat has the potential for epilepsy syndromes research[1][2].

In Vitro

Soticlestat inhibits the catalytic activity of human cholesterol 24-hydroxylase (CH24H) in a concentration-dependent manner with an IC50 of 4.5 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

Soticlestat treatment lowers brain 24S-hydroxycholesterol in a dose-dependent manner and substantially reduceds premature deaths of APP/PS1-Tg mice at a dose lowering brain 24S-hydroxycholesterol by approximately 50%. Soticlestat can suppress potassium-evoked extracellular glutamate elevations in the hippocampus[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Amyloid precursor protein and presenilin 1 (APP/PS1-Tg) mice (7-week-old)[1]
Dosage: 10 mg/kg
Administration: Oral administration; once daily; for 1 days, 3 days and 7 days
Result: Lowered brain 24S-hydroxycholesterol in a dose-dependent manner and substantially reduced premature deaths of APP/PS1-Tg mice at a dose lowering brain 24S-hydroxycholesterol by approximately 50%.
Clinical Trial
Molecular Weight

373.45

Appearance

Solid

Formula

C23H23N3O2
CAS No.
SMILES

O=C(N1CCC(CC2=CC=CC=C2)(O)CC1)C3=C(C4=CC=NC=C4)N=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (267.77 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6777 mL 13.3887 mL 26.7773 mL
5 mM 0.5355 mL 2.6777 mL 5.3555 mL
10 mM 0.2678 mL 1.3389 mL 2.6777 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.69 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.69 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.69 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

Soticlestat1429505-03-2TAK-935 OV935TAK935TAK 935OV935OV 935OV-935Cytochrome P450CYPs24-hydroxylasecholesterolfirst-in-classepilepsyantiepilepticNMDACYP46A1Inhibitorinhibitorinhibit

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