2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. TB-21007

TB-21007 is a selective and brain penetrant α5 subunit-containing GABAA receptor inverse agonist with Kis of 1.6 nM, 20 nM, 16 nM, and 20 nM for α5, α1, α2 and α3 subtypes, respectively. TB-21007 enhances cognition in rats.

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TB-21007

TB-21007 Estructura química

No. CAS : 207306-50-1

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5 mg En stock
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50 mg   Obtener un presupuesto  

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Descripciòn

TB-21007 is a selective and brain penetrant α5 subunit-containing GABAA receptor inverse agonist with Kis of 1.6 nM, 20 nM, 16 nM, and 20 nM for α5, α1, α2 and α3 subtypes, respectively. TB-21007 enhances cognition in rats[1].

In Vivo

TB-21007 (compound 43) (0.3 mg/kg; ip; for 5 days) enhances cognitive performance in rats in the delayed 'matching-to-place' Morris water maze test-a hippocampal-dependent memory task[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male hooded Lister rats were trained in the water maze task[1]
Dosage: 0.3 mg/kg
Administration: ip; for 5 days
Result: Significantly enhanced performance in this hippocampal-dependent memory task.
Peso molecular

339.50

Fòrmula

C15H17NO2S3
No. CAS
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1CC(C)(C)CC2=C(C3=NC=CS3)SC(SCCO)=C21
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvente y solubilidad
In Vitro: 

DMSO : 40 mg/mL (117.82 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9455 mL 14.7275 mL 29.4551 mL
5 mM 0.5891 mL 2.9455 mL 5.8910 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Pureza y Documentación
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9455 mL 14.7275 mL 29.4551 mL 73.6377 mL
5 mM 0.5891 mL 2.9455 mL 5.8910 mL 14.7275 mL
10 mM 0.2946 mL 1.4728 mL 2.9455 mL 7.3638 mL
15 mM 0.1964 mL 0.9818 mL 1.9637 mL 4.9092 mL
20 mM 0.1473 mL 0.7364 mL 1.4728 mL 3.6819 mL
25 mM 0.1178 mL 0.5891 mL 1.1782 mL 2.9455 mL
30 mM 0.0982 mL 0.4909 mL 0.9818 mL 2.4546 mL
40 mM 0.0736 mL 0.3682 mL 0.7364 mL 1.8409 mL
50 mM 0.0589 mL 0.2946 mL 0.5891 mL 1.4728 mL
60 mM 0.0491 mL 0.2455 mL 0.4909 mL 1.2273 mL
80 mM 0.0368 mL 0.1841 mL 0.3682 mL 0.9205 mL
100 mM 0.0295 mL 0.1473 mL 0.2946 mL 0.7364 mL
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TB-21007207306-50-1TB21007TB 21007GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid Receptorselectivebrain penetrantα5 subunit-containing GABAA receptorInhibitorinhibitorinhibit

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Nombre del producto:
TB-21007
Cat. No.:
HY-103510
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