207306-50-1
207306-50-1
Chemical Structure
TB-21007
- CAS No.: 207306-50-1
- Formula:C15H17NO2S3
- Molecular Weight:339.50
IUPAC Name: 3-((2-hydroxyethyl)thio)-6,6-dimethyl-1-(thiazol-2-yl)-6,7-dihydrobenzo[c]thiophen-4(5H)-one
InChIKey: QILRYFCEXLFIDS-UHFFFAOYSA-N
SMILES: O=C1CC(C)(C)CC2=C(C3=NC=CS3)SC(SCCO)=C21
Biological Activity: TB-21007 is a selective and brain penetrant α5 subunit-containing GABAA receptor inverse agonist with Kis of 1.6 nM, 20 nM, 16 nM, and 20 nM for α5, α1, α2 and α3 subtypes, respectively. TB-21007 enhances cognition in rats[1].
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TB-21007 | 99.7% | TB-21007 is a selective and brain penetrant α5 subunit-containing GABAA receptor inverse agonist with Kis of 1.6 nM, 20 nM, 16 nM, and 20 nM for α5, α1, α2 and α3 subtypes, respectively. TB-21007 enhances cognition in rats. | ||||||||||||||||||||
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References
Keywords
