TB-21007
Based on 1 Customer Validation
TB-21007 is a selective and brain penetrant α5 subunit-containing GABAA receptor inverse agonist with Kis of 1.6 nM, 20 nM, 16 nM, and 20 nM for α5, α1, α2 and α3 subtypes, respectively. TB-21007 enhances cognition in rats.
For research use only. We do not sell to patients.
- Purity: 99.7%
- CAS No.: 207306-50-1
- Formula: C15H17NO2S3
- Molecular Weight:339.50
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Male hooded Lister rats were trained in the water maze task[1]
-
Dosage:0.3 mg/kg
-
Administration:ip; for 5 days
-
Result:Significantly enhanced performance in this hippocampal-dependent memory task.
Chemical Information
-
CAS No. 207306-50-1
-
Appearance Solid
-
Molecular Weight 339.50
-
Formula C15H17NO2S3
-
Color Off-white to light yellow
-
SMILES
O=C1CC(C)(C)CC2=C(C3=NC=CS3)SC(SCCO)=C21
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 40 mg/mL (117.82 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (275 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9455 mL | 14.7275 mL | 29.4551 mL | 73.6377 mL |
| 5 mM | 0.5891 mL | 2.9455 mL | 5.8910 mL | 14.7275 mL | |
| 10 mM | 0.2946 mL | 1.4728 mL | 2.9455 mL | 7.3638 mL | |
| 15 mM | 0.1964 mL | 0.9818 mL | 1.9637 mL | 4.9092 mL | |
| 20 mM | 0.1473 mL | 0.7364 mL | 1.4728 mL | 3.6819 mL | |
| 25 mM | 0.1178 mL | 0.5891 mL | 1.1782 mL | 2.9455 mL | |
| 30 mM | 0.0982 mL | 0.4909 mL | 0.9818 mL | 2.4546 mL | |
| 40 mM | 0.0736 mL | 0.3682 mL | 0.7364 mL | 1.8409 mL | |
| 50 mM | 0.0589 mL | 0.2946 mL | 0.5891 mL | 1.4728 mL | |
| 60 mM | 0.0491 mL | 0.2455 mL | 0.4909 mL | 1.2273 mL | |
| 80 mM | 0.0368 mL | 0.1841 mL | 0.3682 mL | 0.9205 mL | |
| 100 mM | 0.0295 mL | 0.1473 mL | 0.2946 mL | 0.7364 mL |
Powered by Bioz