tert-Butyl (10-aminodecyl)carbamate  (Synonyms: 1-Boc-1,10-diaminodecane)

tert-Butyl (10-aminodecyl) carbamate (1-Boc-1,10-diaminodecane) is a synthetic intermediate that serves as a PROTAC linker in PROTAC synthesis and other conjugation applications. tert-Butyl (10-aminodecyl) carbamate is an alkane chain with a terminal amine and a Boc-protected amino group. The amine group can react with carboxylic acids, active NHS esters, carbonyl groups (ketones, aldehydes), etc. The Boc group can be deprotected under mild acidic conditions to form a free amine^[1][2].

tert-Butyl (10-aminodecane) carbamate undergoes amide condensation to yield a Boc-protected intermediate, which is converted into compound 29 (MS479N1, a negative control PROTAC) via a series of reactions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

272.43

C₁₅H₃₂N₂O₂

216961-61-4

Solid-Liquid Mixture

Colorless to off-white

O=C(OC(C)(C)C)NCCCCCCCCCCN

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

• [1]. Deng Z, et al. Harnessing the SPOP E3 Ubiquitin Ligase via a Bridged Proteolysis Targeting Chimera (PROTAC) Strategy for Targeted Protein Degradation. J Med Chem. 2025;68(8):8634-8647.  [Content Brief]

  [2]. Ying S, et al. Selective and Orally Bioavailable c-Met PROTACs for the Treatment of c-Met-Addicted Cancer. J Med Chem. 2024;67(19):17053-17069.  [Content Brief]