1. GPCR/G Protein
    Neuronal Signaling
  2. Cannabinoid Receptor
  3. TM38837

TM38837 

Cat. No.: HY-112340
Handling Instructions

TM38837 is a peripheral selective cannabinoid receptor type 1 (CB1) receptor antagonist. TM38837 shows limited penetrance to the brain in order to minimize or prevent CNS adverse reactions, and preserves potential antiobesity effects. TM38837 reduces propensity for psychiatric side effects.

For research use only. We do not sell to patients.

TM38837 Chemical Structure

TM38837 Chemical Structure

CAS No. : 1253641-65-4

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Description

TM38837 is a peripheral selective cannabinoid receptor type 1 (CB1) receptor antagonist. TM38837 shows limited penetrance to the brain in order to minimize or prevent CNS adverse reactions, and preserves potential antiobesity effects. TM38837 reduces propensity for psychiatric side effects[1][2].

IC50 & Target

CB1

 

In Vivo

TM38837 (10-100 mg/kg; p.o.) induces a significant increase in freezing behavior at 100 mg/kg[1].

Animal Model: 7-8 weeks old male C57BL/6 N mice (B6N)[1]
Dosage: 10, 30, or 100 mg/kg
Administration: p.o.
Result: High dose (100 mg/kg) induced a significant increase in freezing behavior.
Molecular Weight

617.51

Formula

C₃₀H₂₅Cl₂F₃N₄OS

CAS No.

1253641-65-4

SMILES

O=C(C1=NN(C2=CC=C(Cl)C=C2Cl)C(C3=CC=C(C#CC4=CC=C(C(F)(F)F)C=C4)S3)=C1CC)NN5CCCCC5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

TM38837TM 38837TM-38837Cannabinoid Receptorperipheralantiobesityfatmetabolicfear CB1Inhibitorinhibitorinhibit

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TM38837
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