Trifludimoxazin

Name: Trifludimoxazin
Brand: MedChemExpress
SKU: HY-136426
Rating: 4.5 (0 reviews)

製品番号: HY-136426 純度: 98.76%: Data Sheet SDS COA 取扱説明書
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Trifludimoxazin is a click chemistry reagent, a protoporphyrinogen oxidase (PPO) inhibitor and herbicide. Trifludimoxazin inhibits PPO, accumulates reactive oxygen species, damages cell membranes, and thereby causes weed death. Trifludimoxazin exhibits high-efficiency activity in controlling broadleaf weeds and grassy weeds.

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Trifludimoxazin 構造式

CAS 番号 : 1258836-72-4

容量	価格（税別）	在庫状況	数量
5 mg	$82	在庫あり	Estimated Time of Arrival: December 31
10 mg	$130	在庫あり	Estimated Time of Arrival: December 31
50 mg		お問い合わせ
100 mg		お問い合わせ

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Based on 0 publication(s) in Google Scholar

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生物活性
純度とドキュメンテーション
参考文献
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製品説明

体外実験

Trifludimoxazin potently inhibits wild-type and multiple mutant variants of purified A. tuberculatus PPO2 in vitro, with IC₅₀ values as low as 2.45 × 10^-10 M for wild-type enzyme, and retains inhibitory activity against most R128(X) ΔG210 double-mutant enzymes^[1].
Trifludimoxazin (3.35-12.5 g a.i. ha^-1; 7 days post-treatment) reduces growth of transgenic A. thaliana lines ectopically expressing R128(X) ΔG210 double-mutant A. tuberculatus PPO2 at field-relevant doses, with greater efficacy than saflufenacil for most tested mutant variants^[1].
Trifludimoxazin maintains binding affinity to ΔG210, R128G, and G399A mutant A. tuberculatus PPO2 proteins via unique interactions with the enzyme's beta-sheet backbone, which are less affected by common target site mutations than interactions of other PPO inhibitors^[1].
Trifludimoxazin (2-16 g ai ha^-1; 7-20 d postapplication) effectively controls a range of annual broadleaf and grass weed species (including resistant Lolium perenne ssp. multiflorum) in greenhouse postemergence trials when assessed 7 and 20 d postapplication^[2].
Trifludimoxazin (2.7 g ai ha^-1; 24-72 h after application) shows moderate foliar uptake (20-29% for barnyardgrass, 41-90% for Italian ryegrass) with excellent metabolic stability in barnyardgrass and lower stability in Italian ryegrass, and does not translocate to roots in either grass species when assessed 24 and 72 h postapplication^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	E. coli hemG mutants complemented with wild-type or mutant A. tuberculatus PPO2 proteins
Concentration:	10^-5 M (serial 1:5 dilutions in 60% dimethyl sulfoxide)
Incubation Time:	24 h
Result:	Inhibited growth of E. coli hemG mutants expressing wild-type A. tuberculatus PPO2 with an IC₅₀ of 9.27 × 10^-10 M. Inhibited growth of mutants expressing ΔG210 single-mutant PPO2 with an IC₅₀ of 1.18 × 10^-9 M. Inhibited growth of mutants expressing various R128(X) ΔG210 double-mutant PPO2 enzymes with IC₅₀ values ranging from 9.86 × 10^-9 M to 9.00 × 10^-8 M.

分子量

412.34

分子式

C₁₆H₁₁F₃N₄O₄S

CAS 番号

1258836-72-4

Appearance

Solid

Color

Light yellow to khaki

SMILES

O=C(N(C1=C(F)C=C(OC(F)(F)C(N2CC#C)=O)C2=C1)C(N3C)=O)N(C)C3=S

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (242.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4252 mL	12.1259 mL	24.2518 mL
5 mM	0.4850 mL	2.4252 mL	4.8504 mL
10 mM	0.2425 mL	1.2126 mL	2.4252 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

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体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 98.76%

Select Batch:

データシート (278 KB) SDS (252 KB)

COA (254 KB) HNMR (256 KB) LCMS (93 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Porri A, et al. Inhibition profile of trifludimoxazin towards PPO2 target site mutations. Pest Manag Sci. 2023;79(2):507-519.

[2]. Liliana Parra Rapado, et al. Complementary activity of Trifludimoxazin and Saflufenacil when used in combination for postemergence and residual weed control. Weed Sci. 73(e14), 1–11.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4252 mL	12.1259 mL	24.2518 mL	60.6296 mL
	5 mM	0.4850 mL	2.4252 mL	4.8504 mL	12.1259 mL
	10 mM	0.2425 mL	1.2126 mL	2.4252 mL	6.0630 mL
	15 mM	0.1617 mL	0.8084 mL	1.6168 mL	4.0420 mL
	20 mM	0.1213 mL	0.6063 mL	1.2126 mL	3.0315 mL
	25 mM	0.0970 mL	0.4850 mL	0.9701 mL	2.4252 mL
	30 mM	0.0808 mL	0.4042 mL	0.8084 mL	2.0210 mL
	40 mM	0.0606 mL	0.3031 mL	0.6063 mL	1.5157 mL
	50 mM	0.0485 mL	0.2425 mL	0.4850 mL	1.2126 mL
	60 mM	0.0404 mL	0.2021 mL	0.4042 mL	1.0105 mL
	80 mM	0.0303 mL	0.1516 mL	0.3031 mL	0.7579 mL
	100 mM	0.0243 mL	0.1213 mL	0.2425 mL	0.6063 mL