Tubulin-IN-67

Tubulin-IN-67 (Compound 15u) (72 h) potently inhibits the proliferation of Huh7, HeLa, and MCF-7 cancer cells with IC₅₀ values of 0.090 μM, 0.10 μM and 0.12 μM, respectively, and displays a markedly improved safety window relative to CA-4 in normal HUVECs^[1].
Tubulin-IN-67 (0.5-1 μM) functions as a direct microtubule-destabilizing compound that potently inhibits purified tubulin polymerization in vitro^[1].
Tubulin-IN-67 (90-180 nM; 24 h) disrupts the intracellular microtubule network in Huh7 cells, inducing perinuclear microtubule condensation consistent with colchicine-site tubulin inhibition^[1].
Tubulin-IN-67 (90-270 nM; 24 h) induces robust, dose-dependent G₂/M phase cell cycle arrest in Huh7 cells, with the highest tested concentration (270 nM) resulting in 83.16% of cells arrested in G₂/M^[1].
Tubulin-IN-67 (90-270 nM; 48 h) effectively induces dose-dependent apoptosis in Huh7 cells, reaching a total apoptotic rate of 46.6% at the highest tested concentration of 270 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.