UCI-14
Based on 1 Customer Validation
UCI-14 is a gltA1/lprQ modulator with in vitro anti-tuberculosis activity against drug-sensitive and multidrug-resistant mycobacteria. UCI-14 upregulates the expression of genes encoding citrate synthase I, downregulates the expression of genes encoding conserved mycobacterial lipoprotein, and alters the carbon metabolism of mycobacteria. UCI-14 reactivates the expression of wild-type p53 target genes in p53-mutated cells. UCI-14 can be used in the research of tuberculosis and cancer.
For research use only. We do not sell to patients.
- Purity: 98.05%
- CAS No.: 301312-49-2
- Formula: C16H12N2O5
- Molecular Weight:312.28
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
UCI-14 exhibits in vitro antitubercular activity with a consistent MIC of 12.4 µM against drug-sensitive Mycobacterium tuberculosis H37Rv strain and clones 2-3, and MDR Mycobacterium tuberculosis CIBIN:UMF:15:99 strain and clones 1-3, while H37Rv clone 1 shows a higher MIC of 24.8 µM[1].
UCI-14 (12.4-24.8 µM; 4 h) significantly increases gltA1 expression and decreases lprQ expression in drug-sensitive Mycobacterium tuberculosis H37Rv clones, while causing no significant gene expression changes in MDR Mycobacterium tuberculosis CIBIN:UMF:15:99 clones[1].
UCI-14 activates a subset of genes overlapping with wild-type p53 targets in p53-null Saos-2 cells expressing mutant p53 (G245S), as well as in TOV-112D cells with endogenous p53 mutations, with 116 overlapping targets identified in transcriptomic profiling[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Mycobacterium tuberculosis H37Rv
clones -
Concentration:12.4, 24.8 µM
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Incubation Time:4 h
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Result:Increased gltA1 expression and decreases lprQ expression in drug-sensitive Mycobacterium tuberculosis H37Rv clones.
Chemical Information
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CAS No. 301312-49-2
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Appearance Solid
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Molecular Weight 312.28
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Formula C16H12N2O5
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Color Orange to red
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SMILES
O=C1NC(/C(C(N1)=O)=C/C2=CC=C(C3=CC=C(OC)C=C3)O2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 7 mg/mL (22.42 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2023 mL | 16.0113 mL | 32.0225 mL | 80.0564 mL |
| 5 mM | 0.6405 mL | 3.2023 mL | 6.4045 mL | 16.0113 mL | |
| 10 mM | 0.3202 mL | 1.6011 mL | 3.2023 mL | 8.0056 mL | |
| 15 mM | 0.2135 mL | 1.0674 mL | 2.1348 mL | 5.3371 mL | |
| 20 mM | 0.1601 mL | 0.8006 mL | 1.6011 mL | 4.0028 mL |
UCI-14 Related Classifications
HY-201256 Related Classifications
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