301312-49-2
Chemical Structure
UCI-14
- CAS No.: 301312-49-2
- Formula:C16H12N2O5
- Molecular Weight:312.28
InChIKey: UOURPSZIXKPGMH-UHFFFAOYSA-N
SMILES: O=C1NC(/C(C(N1)=O)=C/C2=CC=C(C3=CC=C(OC)C=C3)O2)=O
Biological Activity: UCI-14 is a gltA1/lprQ modulator with in vitro anti-tuberculosis activity against drug-sensitive and multidrug-resistant mycobacteria. UCI-14 upregulates the expression of genes encoding citrate synthase I, downregulates the expression of genes encoding conserved mycobacterial lipoprotein, and alters the carbon metabolism of mycobacteria. UCI-14 reactivates the expression of wild-type p53 target genes in p53-mutated cells. UCI-14 can be used in the research of tuberculosis and cancer[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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UCI-14 | 98.05% | UCI-14 is a gltA1/lprQ modulator with in vitro anti-tuberculosis activity against drug-sensitive and multidrug-resistant mycobacteria. UCI-14 upregulates the expression of genes encoding citrate synthase I, downregulates the expression of genes encoding conserved mycobacterial lipoprotein, and alters the carbon metabolism of mycobacteria. UCI-14 reactivates the expression of wild-type p53 target genes in p53-mutated cells. UCI-14 can be used in the research of tuberculosis and cancer. | ||||||||||||||||||||
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References
- [1]. Penuelas-Urquides K, et al. Two New Dihydrosphingosine Analogs Against Mycobacterium tuberculosis Affect gltA1, lprQ, and rpsO Expression. Front Microbiol. 2021;12:742867.
- [2]. Law F, et al. Second-Site Rescue Mutants as Tools to Uncover Reactivation Mechanisms of p53 Cancer Mutants. Department of Biological Chemistry, Chao Family Comprehensive Cancer Center, University of California, Irvine; 2025.
