2. Anti-infection Apoptosis
  3. Bacterial Apoptosis
  4. Vitexilactone

Vitexilactone is a diterpenoid that can be isolated from the leaves of Vitex negundo L. Vitexilactone shows antimicrobial activity towards E. coli. Vitexilactone induces cell apoptosis and inhibits cell cycle of cancer cells. Vitexilactone can be used for the research of cancer.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Vitexilactone

Vitexilactone 화학구조

CAS No. : 61263-49-8

사이즈 가격 재고 수량
1 mg 해외재고보유
5 mg 해외재고보유
10 mg   견적 받기  
50 mg   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

Vitexilactone Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

Vitexilactone is a diterpenoid that can be isolated from the leaves of Vitex negundo L. Vitexilactone shows antimicrobial activity towards E. coli. Vitexilactone induces cell apoptosis and inhibits cell cycle of cancer cells. Vitexilactone can be used for the research of cancer[1][2].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
< 5 6
Compound: Vitexilactone
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
[PMID: 23327905]
A549 IC50
<5 6
Compound: Vitexilactone
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
[PMID: 23327905]
A549 IC50
< 5 6
Compound: Vitexilactone
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
[PMID: 23327905]
HCT-116 GI50
> 5000 14
Compound: 13
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 11975496]
HCT-116 IC50
< 5 6
Compound: Vitexilactone
Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay
Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay
[PMID: 23327905]
HCT-116 GI50
>5000 14
Compound: 13
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 11975496]
HCT-116 GI50
> 5000 14
Compound: 13
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 11975496]
HCT-116 IC50
<5 6
Compound: Vitexilactone
Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay
Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay
[PMID: 23327905]
HCT-116 IC50
< 5 6
Compound: Vitexilactone
Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay
Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay
[PMID: 23327905]
HL-60 IC50
< 5 6
Compound: Vitexilactone
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
[PMID: 23327905]
HL-60 IC50
<5 6
Compound: Vitexilactone
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
[PMID: 23327905]
HL-60 IC50
< 5 6
Compound: Vitexilactone
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
[PMID: 23327905]
PC-12 GI50
> 5000 14
Compound: 13
Cytotoxicity against rat PC12 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against rat PC12 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 11975496]
PC-12 GI50
> 5000 14
Compound: 13
Cytotoxicity against rat PC12 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against rat PC12 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 11975496]
PC-12 GI50
>5000 14
Compound: 13
Cytotoxicity against rat PC12 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against rat PC12 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 11975496]
RAW264.7 IC50
42.5 3
Compound: 1
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
[PMID: 24035341]
RAW264.7 IC50
42.5 3
Compound: 1
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
[PMID: 24035341]
ZR-75-30 IC50
< 5 6
Compound: Vitexilactone
Cytotoxicity against human ZR75-30 cells after 72 hrs by MTT assay
Cytotoxicity against human ZR75-30 cells after 72 hrs by MTT assay
[PMID: 23327905]
ZR-75-30 IC50
<5 6
Compound: Vitexilactone
Cytotoxicity against human ZR75-30 cells after 72 hrs by MTT assay
Cytotoxicity against human ZR75-30 cells after 72 hrs by MTT assay
[PMID: 23327905]
RAW264.7 IC50
42.5 3
Compound: 1
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
[PMID: 24035341]
ZR-75-30 IC50
< 5 6
Compound: Vitexilactone
Cytotoxicity against human ZR75-30 cells after 72 hrs by MTT assay
Cytotoxicity against human ZR75-30 cells after 72 hrs by MTT assay
[PMID: 23327905]
In Vitro

Vitexilactone shows significant antimicrobial activity towards E. coli with an MIC value ＞90 μg/mL[1].
Vitexilactone (0-100 μg/mL; 17-24 h) inhibits cell proliferation of mammalian cancer cells[2].
Vitexilactone (25-100 μg/mL; 17 h) induces cell apoptosis at higher concentrations, while inhibits the cell cycle G0/G1 phase at lower concentrations of tsFT210 and K562 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Vitexilactone Related Antibodies

Cell Proliferation Assay[2]

Cell Line: tsFT210 and K562 cells lines
Concentration: 0-100 μg/mL
Incubation Time: 17-24 hours
Result: Inhibited cell proliferation of mammalian cancer cells with IC50 values of 86.9 and 57.9 μg/mL for tsFT210 and K562 cells, respectively.

Apoptosis Analysis[2]

Cell Line: tsFT210 and K562 cell lines
Concentration: 25-100 μg/mL
Incubation Time: 17 hours
Result: Induced cell apoptosis of tsFT210 with a MIC value of 25 μg/mL.

Cell Cycle Analysis[2]

Cell Line: tsFT210 and K562 cell lines
Concentration: 25-100 μg/mL
Incubation Time: 17 hours
Result: Inhibited G0/G1 phase of cell cycle with the dose ranges of 50-6.25 μg/mL in tsFT210 cells.
분자량

378.50

화학식

C22H34O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1OCC(CC[C@@]2(O)[C@H](C)C[C@@H](OC(C)=O)[C@@]3([H])C(C)(C)CCC[C@]23C)=C1
Structure Classification
Initial Source
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
순도&문서

Purity: 97.67%

SDS (251 KB)

COA (251 KB) HNMR (170 KB) LCMS (130 KB)

Handling Instructions (2659 KB)
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Vitexilactone Related Classifications

  • 몰농도 계산기

  • 농도 희석 계산기

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vitexilactone61263-49-8BacterialApoptosisditerpenoidnatural productantimicrobialapoptosiscell cyclecancertsFT210K562Inhibitorinhibitorinhibit

최근 본 상품:

온라인 문의

Your information is safe with us. * Required Fields.

상품명

  

Requested Quantity *

고객명 *

 

호칭

메일주소 *

 

전화번호 *

Department

 

회사명 *

City

도

Country or Region *

      

비고

대량구매 문의

Inquiry Information

상품명:
Vitexilactone
Cat. No.:
HY-N1079
수량:
MCE Japan Authorized Agent:

고객리뷰

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

상품명

  

Lot #

고객명 *

 

메일주소 *

전화번호

 

Department *

회사명 *

 

Country or Region *

비고

SAFETY DATA SHEET (SDS)

English - EN (251 KB) Français - FR (251 KB) Deutsch - DE (251 KB) Norwegian - NO (251 KB) Español - ES (251 KB) Swedish - SV (251 KB) Italian - IT (251 KB) Korean - KR (251 KB) Portuguese - PT (251 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.