Xylometazoline 

Xylometazoline is an α-adrenergic receptor agonist (K_i=0.05-1.7 μM). Xylometazoline can constrict nasal blood vessels and increase nasal airflow. Xylometazoline hydrochloride can be used in nose stuffiness and runny nose research^[1][2][3][4].

Xylometazoline has affinity for α1A-adrenoceptor and α2B-adrenoceptor in HEK293 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Xylometazoline (1 mg/mL, intranasal, single dose) improves sinusitis in rats^[3].
Xylometazoline and its excipients, when used for prolonged periods, may cause ophthalmic problems such as dry eyes, corneal edema, cataracts, retinal nerve fiber layer damage, and vascular damage^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

244.38

C₁₆H₂₄N₂

526-36-3

CC1=C(CC2=NCCN2)C(C)=CC(C(C)(C)C)=C1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Ronald Eccles, et al. The nasal decongestant effect of xylometazoline in the common cold. Am J Rhinol. 2008 Sep-Oct;22(5):491-6.  [Content Brief]

  [2]. Britta Haenisch, et al. Alpha-adrenoceptor agonistic activity of oxymetazoline and xylometazoline. Fundam Clin Pharmacol. 2010 Dec;24(6):729-39.  [Content Brief]

  [3]. M Kar, et al. Development of an intranasal formulation containing indomethacin and xylometazoline for rhinosinusitis treatment. Eur Rev Med Pharmacol Sci. 2022 Dec;26(2 Suppl):65-71.  [Content Brief]

  [4]. Ayse Ipek Akyuz Unsal, et al. Ophthalmic adverse effects of nasal decongestants on an experimental rat model. Arq Bras Oftalmol. 2018 Jan-Feb;81(1):53-58.  [Content Brief]