526-36-3
526-36-3
Chemical Structure
Xylometazoline
- CAS. Nr.: 526-36-3
- Formula:C16H24N2
- Molecular Weight:244.38
IUPAC Name: 2-(4-(tert-butyl)-2,6-dimethylbenzyl)-4,5-dihydro-1H-imidazole
InChIKey: HUCJFAOMUPXHDK-UHFFFAOYSA-N
SMILES: CC1=C(CC2=NCCN2)C(C)=CC(C(C)(C)C)=C1
Biological Activity: Xylometazoline is an α-adrenergic receptor agonist (Ki=0.05-1.7 μM). Xylometazoline can constrict nasal blood vessels and increase nasal airflow. Xylometazoline hydrochloride can be used in nose stuffiness and runny nose research[1][2][3][4].
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Xylometazoline | Xylometazoline is an α-adrenergic receptor agonist (Ki=0.05-1.7 μM). Xylometazoline can constrict nasal blood vessels and increase nasal airflow. Xylometazoline hydrochloride can be used in nose stuffiness and runny nose research. | |||||||||||||||||||||
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References
- [1]. Ronald Eccles, et al. The nasal decongestant effect of xylometazoline in the common cold. Am J Rhinol. 2008 Sep-Oct;22(5):491-6. [Content Brief]
- [2]. Britta Haenisch, et al. Alpha-adrenoceptor agonistic activity of oxymetazoline and xylometazoline. Fundam Clin Pharmacol. 2010 Dec;24(6):729-39. [Content Brief]
- [3]. M Kar, et al. Development of an intranasal formulation containing indomethacin and xylometazoline for rhinosinusitis treatment. Eur Rev Med Pharmacol Sci. 2022 Dec;26(2 Suppl):65-71. [Content Brief]
- [4]. Ayse Ipek Akyuz Unsal, et al. Ophthalmic adverse effects of nasal decongestants on an experimental rat model. Arq Bras Oftalmol. 2018 Jan-Feb;81(1):53-58. [Content Brief]
Keywords
