2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Xylometazoline

Xylometazoline is an α-adrenergic receptor agonist (Ki=0.05-1.7 μM). Xylometazoline can constrict nasal blood vessels and increase nasal airflow. Xylometazoline hydrochloride can be used in nose stuffiness and runny nose research.

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Xylometazoline

Xylometazoline Chemical Structure

CAS No. : 526-36-3

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Xylometazoline Related Antibodies

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Description

Xylometazoline is an α-adrenergic receptor agonist (Ki=0.05-1.7 μM). Xylometazoline can constrict nasal blood vessels and increase nasal airflow. Xylometazoline hydrochloride can be used in nose stuffiness and runny nose research[1][2][3][4].

IC50 & Target[2]

Alpha-1A adrenergic receptor

0.05 μM (Ki)

Alpha-1B adrenergic receptor

0.30 μM (Ki)

Alpha-1D adrenergic receptor

0.15 μM (Ki)

Alpha-2A adrenergic receptor

0.88 μM (Ki)

Alpha-2B adrenergic receptor

1.7 μM (Ki)

Alpha-2C adrenergic receptor

0.19 μM (Ki)

In Vitro

Xylometazoline has affinity for α1A-adrenoceptor and α2B-adrenoceptor in HEK293 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Xylometazoline Related Antibodies
In Vivo

Xylometazoline (1 mg/mL, intranasal, single dose) improves sinusitis in rats[3].
Xylometazoline and its excipients, when used for prolonged periods, may cause ophthalmic problems such as dry eyes, corneal edema, cataracts, retinal nerve fiber layer damage, and vascular damage[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SpragueDawley rat induced by platelet-activating factor[3]
Dosage: 1 mg/mL; single dose
Administration: Intranasal administration
Result: Showed almost no vascular congestion, little infiltration, and the epithelium was completely intact.
Essai clinique
Masse moléculaire

244.38

Formule

C16H24N2
CAS No.
SMILES

CC1=C(CC2=NCCN2)C(C)=CC(C(C)(C)C)=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
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Xylometazoline Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Xylometazoline526-36-3Adrenergic ReceptorBeta Receptorconstrict nasal blood vesselsincrease nasal airflownose stuffinessrunny noseInhibitorinhibitorinhibit

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