Y-27632 dihydrochloride

Name: Y-27632 dihydrochloride
Brand: MedChemExpress
SKU: HY-10583G
Rating: 5.0 (1 reviews)

製品番号: HY-10583G: Data Sheet SDS 取扱説明書
FAQs
Technical Support

Y-27632 dihydrochloride (GMP) is the GMP level of Y-27632 dihydrochloride (HY-10583). GMP guidelines are used to produce Y-27632 dihydrochloride (GMP). GMP small molecules works appropriately as an auxiliary reagent for cell research manufacture. Y-27632 dihydrochloride is an orally active and ATP-competitive ROCK (Rho-kinase) inhibitor with antiepileptic effect.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Y-27632 dihydrochloride 構造式

CAS 番号 : 129830-38-2

容量	価格（税別）	在庫状況	数量
10 mg	$1280	在庫あり	Estimated Time of Arrival: December 31
50 mg	$3600	在庫あり	Estimated Time of Arrival: December 31
100 mg	$5760	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

顧客検証

•Dev Cell. 2025 Jun 23;60(12):1751-1767.e9. [Abstract]

ROCK アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

ROCK ROCK1 ROCK2

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

体外実験

Y-27632 dihydrochloride (GMP) (2 μM; 4-8 d) enhances the survival rate and inreases reprogramming of mouse fibroblasts directly converted into neuronal cells^[1].
Y-27632 dihydrochloride (GMP) induces human fibroblasts convert into functional cardiomyocytes^[2].
Y-27632 dihydrochloride (GMP) induces fibroblasts convert into pluripotent stem cells (hiPSCs)^[2].
Y-27632 dihydrochloride (GMP) (2-10 μM) promotes human EPS cell proliferation and induces primed hPSCs convert into hEPS cells^[3].
Y-27632 dihydrochloride (GMP) (10 μM) induces human EPS cell derivated from blastocysts^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

320.26

分子式

C₁₄H₂₃Cl₂N₃O

CAS 番号

129830-38-2

Appearance

Solid

Color

White to off-white

SMILES

O=C([C@@H]1CC[C@]([C@H](N)C)([H])CC1)NC2=CC=NC=C2.[H]Cl.[H]Cl

輸送条件

Shipping with dry ice.

保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

溶剤 & 溶解度

体外:

H₂O : 100 mg/mL (312.25 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1225 mL	15.6123 mL	31.2246 mL
5 mM	0.6245 mL	3.1225 mL	6.2449 mL
10 mM	0.3122 mL	1.5612 mL	3.1225 mL

View the Complete Stock Solution Preparation Table

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

純度とドキュメンテーション

データシート (272 KB) SDS (393 KB) 取扱説明書 (2659 KB)

参考文献

[1]. Li X, et al. Small-Molecule-Driven Direct Reprogramming of Mouse Fibroblasts into Functional Neurons. Cell Stem Cell. 2015 Aug 6;17(2):195-203. [Content Brief]

[2]. Cao N, et al. Conversion of human fibroblasts into functional cardiomyocytes by small molecules. Science. 2016 Jun 3;352(6290):1216-20. [Content Brief]

[3]. Choi IY, et al. Concordant but Varied Phenotypes among Duchenne Muscular Dystrophy Patient-Specific Myoblasts Derived using a Human iPSC-Based Model. Cell Rep. 2016 Jun 7;15(10):2301-2312. [Content Brief]

[4]. Yang Y, et al. Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency. Cell. 2017 Apr 6;169(2):243-257.e25. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	3.1225 mL	15.6123 mL	31.2246 mL	78.0616 mL
	5 mM	0.6245 mL	3.1225 mL	6.2449 mL	15.6123 mL
	10 mM	0.3122 mL	1.5612 mL	3.1225 mL	7.8062 mL
	15 mM	0.2082 mL	1.0408 mL	2.0816 mL	5.2041 mL
	20 mM	0.1561 mL	0.7806 mL	1.5612 mL	3.9031 mL
	25 mM	0.1249 mL	0.6245 mL	1.2490 mL	3.1225 mL
	30 mM	0.1041 mL	0.5204 mL	1.0408 mL	2.6021 mL
	40 mM	0.0781 mL	0.3903 mL	0.7806 mL	1.9515 mL
	50 mM	0.0624 mL	0.3122 mL	0.6245 mL	1.5612 mL
	60 mM	0.0520 mL	0.2602 mL	0.5204 mL	1.3010 mL
	80 mM	0.0390 mL	0.1952 mL	0.3903 mL	0.9758 mL
	100 mM	0.0312 mL	0.1561 mL	0.3122 mL	0.7806 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.