1. Cytoskeleton
  2. Integrin
  3. Zaurategrast

Zaurategrast (Synonyms: CT7758)

Cat. No.: HY-70073 Purity: 98.81%
Handling Instructions

Zaurategrast (CT7758) is a potent and oral-effective α4-integrin inhibitor.

For research use only. We do not sell to patients.

Zaurategrast Chemical Structure

Zaurategrast Chemical Structure

CAS No. : 455264-31-0

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 234 In-stock
Estimated Time of Arrival: December 31
5 mg USD 204 In-stock
Estimated Time of Arrival: December 31
10 mg USD 360 In-stock
Estimated Time of Arrival: December 31
25 mg USD 708 In-stock
Estimated Time of Arrival: December 31
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Zaurategrast (CT7758) is a potent and oral-effective α4-integrin inhibitor.

IC50 & Target


In Vitro

CDP323 is an ethyl ester prodrug of CT7758, a potent carboxylic acid antagonist of α4β1 (very late antigen-4, VLA-4) and, to a lesser extent, α4β7 integrins. CDP323 is developed as a VLA-4 antagonist prodrug for the treatment of multiple sclerosis[2].

In Vivo

CDP323 is a potent and effective α4 inhibitor that is well tolerated at oral doses up to 1000 mg twice daily (bid). Relative to placebo, all dosages of Zaurategrast (CDP-323) significantly decreased the capacity of lymphocytes to bind vascular adhesion molecule-1 (VCAM-1) and the expression of α4-integrin on VCAM-1-binding cells. CDP323 at daily doses of 1000 or 2000 mg induced significant increases in total lymphocyte count and suppressed VCAM-1 binding by reducing unbound very late antigen-4 expression on lymphocytes[1]. After oral administration of CDP323, CT7758 is by far the most abundant circulating plasma component, peaking between 0.5 and 1.5 hours irrespective of the species. These data suggested that CDP323 is rapidly absorbed and efficiently hydrolyzed into CT7758. Plasma exposure of CT7758 showed a large species variability with dog>rat=mice>cynomolgus monkey. In the tested dose range of 25-50 mg/kg, the estimated oral bioavailability (i.e., based on intravenous administration of CT7758 and assuming linear PK) is 29, 27, 8, and 0.3% in mice, rat, dog, and cynomolgus monkey, respectively. CDP323 increased the absorption of CT7758 by 5- to 10-fold in rodents, whereas no significant increase is observed in dog and monkey[3].

Molecular Weight







O=C1C(Br)=C(C12CCCCC2)N[[email protected]](C(O)=O)CC3=CC=C(NC4=NC=CC5=CC=NC=C45)C=C3


Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (191.79 mM; Need ultrasonic)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9179 mL 9.5894 mL 19.1788 mL
5 mM 0.3836 mL 1.9179 mL 3.8358 mL
10 mM 0.1918 mL 0.9589 mL 1.9179 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 3.25 mg/mL (6.23 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 3.25 mg/mL (6.23 mM); Clear solution

*All of the co-solvents are provided by MCE.
Animal Administration

Male Wistar rats (250-320 g) and CD-1 mice (20-25 g), Non-naive male Beagle dogs weighing 10 kg, and non-naive male cynomolgus monkeys weighing 3 kg are used. For plasma pharmacokinetic studies, CT7758 is administered orally (5-10 mL/kg, 30 mg/kg) or intravenously (2 mL/kg, 3 mg/kg) as a solution in 10 mM phosphate buffer. CDP323 is administered orally as a 1% methylcellulose suspension containing 0.1% Tween 80 (same dosage volume as CT7758). Compounds are delivered to fasted animals with the food returned 4 hours postdose. Blood samples are collected at the designated time points. Plasma is prepared by centrifugation, collected, and stored at −20°C until analysis by liquid chromatography-tandem mass spectrometry (LC-MS/MS).

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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ZaurategrastCT7758CT 7758CT-7758IntegrinInhibitorinhibitorinhibit

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