2. Anti-infection
  3. Bacterial
  4. α-Lactalbumin

α-Lactalbumin is a globular whey protein that exists in milk. α-Lactalbumin binds Ca2+, Mg2+, Mn2+, Na+, K+ and Zn2+ ions; among these, Ca2+ binding enhances protein stability, while Zn2+ binding reduces stability and induces aggregation. α-Lactalbumin forms amyloid fibrils, amorphous aggregates, nanoparticles and nanotubes depending on external conditions. α-Lactalbumin exhibits bactericidal and antiviral activities. α-Lactalbumin has anxiolytic and antidepressant activities, and its effects are enhanced under stress conditions.

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α-Lactalbumin

α-Lactalbumin Chemical Structure

CAS No. : 9051-29-0

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Based on 1 publication(s) in Google Scholar

Other Forms of α-Lactalbumin:

α-Lactalbumin Related Antibodies

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Description

α-Lactalbumin is a globular whey protein that exists in milk. α-Lactalbumin binds Ca2+, Mg2+, Mn2+, Na+, K+ and Zn2+ ions; among these, Ca2+ binding enhances protein stability, while Zn2+ binding reduces stability and induces aggregation. α-Lactalbumin forms amyloid fibrils, amorphous aggregates, nanoparticles and nanotubes depending on external conditions. α-Lactalbumin exhibits bactericidal and antiviral activities. α-Lactalbumin has anxiolytic and antidepressant activities, and its effects are enhanced under stress conditions[1][2][3].

In Vitro

Acylated and esterified derivatives of bovine α-Lactalbumin possess broad-spectrum antiviral activity against HIV-1, HIV-2, HSV-1, cytomegalovirus, and avian influenza H5N1[1].
α-Lactalbumin is a component of lactose synthase, an enzyme system, which consists of galactosyltransferase (GT) and α-Lactalbumin[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

α-Lactalbumin Related Antibodies
In Vivo

α-Lactalbumin (18.8 g/100 g; dietary; ad libitum daily; 30 days) reduces weight gain, decreases aggressive behaviour relative to casein-fed mice (matching levels seen in whey-fed mice), and modulates anxiety- and depression-like behaviours in male C57BL/6J mice, with effects that persist and show context-dependent changes for 7 days after diet withdrawal[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J (male, 2.5 months old)[3]
Dosage: 18.8 g/100 g (diet content)
Administration: dietary; ad libitum daily; 30 days
Result: Reduced weight gain significantly compared to casein-fed mice.
Decreased aggressive behaviour to 29% in group social tests.
Spent less time (124 s) and had lower mobility (102 s) in the light compartment of the light-dark box test.
Travelled a longer distance (1235 mm) in protected zones of the elevated-plus maze.
Showed longer total duration (15.4) and higher total frequency (8.8) of freezing behaviour near a new object in the open-field test.
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[a-Lactalbumin]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 99.9%

SDS (251 KB)

COA (230 KB)

Handling Instructions (2659 KB)
References
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α-Lactalbumin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-Lactalbumin9051-29-0BacterialGram-positive bacteriatumor cellslactose synthasegalactosyltransferaseHIV-1zinc ionscalcium ionsglioblastomaskin papillomassuperficial transitional cell carcinomasInhibitorinhibitorinhibit

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