β-Cembrenediol 

β-Cembrenediol is a potent and orally active anticancer agent. β-Cembrenediol shows phytotoxic activities. β-Cembrenediol reduces the migration and colony formation. β-Cembrenediol decreases the protein expression of TDO2, IDO1. β-Cembrenediol has the potential for the research of prostate cancer^[1][2].

β-Cembrenediol (25, 50, 100, 200 µg/mL) shows inhibition on lettuce seedling stem length and root length in a dose-dependent manner^[1].
β-Cembrenediol (0, 0.2, 0.5, 1, 5, 10 µM) reduces the migration and colony formation in a dose-dependent manner^[2].
β-Cembrenediol (5, 10, 20 µM; 48 h) decreases the protein expression of TDO2, IDO1 in a dose-dependent manner^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

β-Cembrenediol (15 mg/kg; p.o.; daily for 8 weeks) shows anti-tumor activity in prostate cancer mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

306.48

C₂₀H₃₄O₂

57605-81-9

Solid

White to off-white

O[C@]1(C)C[C@@H](O)/C=C(C)/CC/C=C(C)/CC[C@@H](C(C)C)/C=C/1

Room temperature in continental US; may vary elsewhere.

• [1]. Ren X, et al. Isolation, Identification, and Autotoxicity Effect of Allelochemicals from Rhizosphere Soils of Flue-Cured Tobacco. J Agric Food Chem. 2015 Oct 21;63(41):8975-80.  [Content Brief]

  [2]. Mudhish EA, et al. The Tobacco β-Cembrenediol: A Prostate Cancer Recurrence Suppressor Lead and Prospective Scaffold via Modulation of Indoleamine 2,3-Dioxygenase and Tryptophan Dioxygenase. Nutrients. 2022 Apr 4;14(7):1505.  [Content Brief]