1. Metabolic Enzyme/Protease
  2. Drug Metabolite
  3. ω-Hydroxy-DEET

ω-Hydroxy-DEET 

Cat. No.: HY-136611
Handling Instructions

ω-Hydroxy-DEET is a major metabolite of insect repellent N-N-diethyl-meta-toluamide (DEET). ω-Hydroxy-DEET has anti-proliferative effects. DEET is a spatial repellent and an irritant that commonly used to prevent contact with mosquitoes.

For research use only. We do not sell to patients.

ω-Hydroxy-DEET Chemical Structure

ω-Hydroxy-DEET Chemical Structure

CAS No. : 72236-22-7

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Description

ω-Hydroxy-DEET is a major metabolite of insect repellent N-N-diethyl-meta-toluamide (DEET). ω-Hydroxy-DEET has anti-proliferative effects. DEET is a spatial repellent and an irritant that commonly used to prevent contact with mosquitoes[1][2][3].

In Vitro

Hepatoma cell studies reveals that ω-Hydroxy-DEET (DHMB; 0.1-10 μg/mL; 48-72 hours) treatments decreases cellular proliferation[1].

In Vivo

The metabolite ω-Hydroxy-DEET (DHMB) is extensively distributed following intravenous and topical skin administration of DEET in rats. The ω-Hydroxy-DEET appeared to be the major metabolite for DEET. Repeated once-daily topical application for 30 days lead to higher concentrations of ω-Hydroxy-DEET in the liver[1].

Molecular Weight

207.27

Formula

C₁₂H₁₇NO₂

CAS No.

72236-22-7

SMILES

O=C(N(CC)CC)C1=CC=CC(CO)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

ω-Hydroxy-DEETDrug MetaboliteDHMBmajormetaboliteDEETanti-proliferativespatialrepellentirritantInhibitorinhibitorinhibit

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