1-Methylhistamine-d₃ dihydrochloride

製品番号: HY-W053787S 純度: 99.91%: Data Sheet SDS COA 取扱説明書
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1-Methylhistamine-d₃ (dihydrochloride) is the deuterium labeled 1-Methylhistamine (dihydrochloride). 1-Methylhistamine dihydrochloride is a histamine metabolite.

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1-Methylhistamine-d<sub>3</sub> dihydrochloride

1-Methylhistamine-d₃ dihydrochloride 構造式

CAS 番号 : 344299-49-6

容量	価格（税別）	在庫状況	数量
1 mg	$70	在庫あり	Estimated Time of Arrival: December 31
5 mg	$245	在庫あり	Estimated Time of Arrival: December 31
10 mg		お問い合わせ
50 mg		お問い合わせ

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* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

Other Forms of 1-Methylhistamine-d₃ dihydrochloride:

1-Methylhistamine dihydrochloride 在庫あり
1-Methylhistamine お問い合わせ

Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

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生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

1-Methylhistamine-d₃ (dihydrochloride) is the deuterium labeled 1-Methylhistamine (dihydrochloride)^[1]. 1-Methylhistamine dihydrochloride is a histamine metabolite^[2].

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

体外実験

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

201.11

分子式

C₆H₁₀D₃Cl₂N₃

CAS 番号

344299-49-6

Unlabeled CAS

501-75-7

Appearance

Solid

Color

White to off-white

SMILES

NCCC1=CN(C([2H])([2H])[2H])C=N1.Cl.Cl

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

溶剤 & 溶解度

体外:

H2O : 62.5 mg/mL (310.78 mM; Need ultrasonic and warming)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.9724 mL	24.8620 mL	49.7240 mL
5 mM	0.9945 mL	4.9724 mL	9.9448 mL
10 mM	0.4972 mL	2.4862 mL	4.9724 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

純度とドキュメンテーション

純度: 99.91%

Select Batch:

データシート (271 KB) SDS (252 KB)

COA (248 KB) HNMR (770 KB) RP-HPLC (286 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]

[2]. Saito K, et al. Determination of urinary excretion of histamine and 1-methylhistamine by liquid chromatography. J Chromatogr B Biomed Appl. 1994 Apr 1;654(2):270-5. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H2O	1 mM	4.9724 mL	24.8620 mL	49.7240 mL	124.3101 mL
	5 mM	0.9945 mL	4.9724 mL	9.9448 mL	24.8620 mL
	10 mM	0.4972 mL	2.4862 mL	4.9724 mL	12.4310 mL
	15 mM	0.3315 mL	1.6575 mL	3.3149 mL	8.2873 mL
	20 mM	0.2486 mL	1.2431 mL	2.4862 mL	6.2155 mL
	25 mM	0.1989 mL	0.9945 mL	1.9890 mL	4.9724 mL
	30 mM	0.1657 mL	0.8287 mL	1.6575 mL	4.1437 mL
	40 mM	0.1243 mL	0.6216 mL	1.2431 mL	3.1078 mL
	50 mM	0.0994 mL	0.4972 mL	0.9945 mL	2.4862 mL
	60 mM	0.0829 mL	0.4144 mL	0.8287 mL	2.0718 mL
	80 mM	0.0622 mL	0.3108 mL	0.6216 mL	1.5539 mL
	100 mM	0.0497 mL	0.2486 mL	0.4972 mL	1.2431 mL