2. Cytoskeleton
  3. Collagen
  4. 12-O-Tiglyl-phorbol 13-dodecanoate

12-O-Tiglyl-phorbol 13-dodecanoate (TD13) is a potential inhibitor with anti-hepatic fibrosis activity, and it belongs to a series of derivatives of oral APOL2 inhibitors and anti-hepatic fibrosis agents. It shows no obvious toxicity in preclinical models. Compounds of the 12-O-Tiglyl-phorbol 13-dodecanoate series inhibit the expression of fibronectin, type I collagen and α-smooth muscle actin in hepatic stellate cells. 12-O-Tiglyl-phorbol 13-dodecanoate can be isolated from the Euphorbiaceae plant Euphorbia fischeriana, and it is applicable to the research of hepatic fibrosis.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

12-O-Tiglyl-phorbol 13-dodecanoate

12-O-Tiglyl-phorbol 13-dodecanoate Chemical Structure

CAS No. : 37394-32-4

Size Stock
50 mg   Obtenir un devis  
100 mg   Obtenir un devis  
250 mg   Obtenir un devis  

* Veuillez sélectionner la quantité avant d'ajouter des articles.

This product is a controlled substance and not for sale in your territory.

12-O-Tiglyl-phorbol 13-dodecanoate Related Antibodies

Top Publications Citing Use of Products

  • Activité biologique

  • Pureté et documentation

  • Références

  • Avis client

Description

12-O-Tiglyl-phorbol 13-dodecanoate (TD13) is a potential inhibitor with anti-hepatic fibrosis activity, and it belongs to a series of derivatives of oral APOL2 inhibitors and anti-hepatic fibrosis agents. It shows no obvious toxicity in preclinical models. Compounds of the 12-O-Tiglyl-phorbol 13-dodecanoate series inhibit the expression of fibronectin, type I collagen and α-smooth muscle actin in hepatic stellate cells. 12-O-Tiglyl-phorbol 13-dodecanoate can be isolated from the Euphorbiaceae plant Euphorbia fischeriana, and it is applicable to the research of hepatic fibrosis[1].

IC50 & Target[1]

Collagen I

 

In Vitro

The 12-O-Tiglyl-phorbol 13-dodecanoate homologue TD1 (10 μM; 48 h) significantly inhibits fibronectin expression in TGF-β1-stimulated LX-2 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

12-O-Tiglyl-phorbol 13-dodecanoate Related Antibodies
In Vivo

The 12-O-Tiglyl-phorbol 13-dodecanoate analog TD1 (5-20 mg/kg; p.o.; once every 2 days; 5 w) dose-dependently ameliorates carbon tetrachloride (HY-Y0298)-induced liver fibrosis in mice, with the efficacy at the 20 mg/kg dose comparable to that of 200 mg/kg Pirfenidone (HY-B0673)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J mice with Liver fibrosis (8-week-old male, carbon tetrachloride-induced liver fibrosis)[1]
Dosage: 12-O-Tiglyl-phorbol 13-dodecanoate analog TD1:
5 mg/kg; 10 mg/kg; 20 mg/kg
Administration: p.o.; once every 2 days; 5 weeks
Result: Reduced liver inflammatory cell infiltration and fibrous proliferation in a dose-dependent manner.
Decreased serum alanine aminotransferase, aspartate aminotransferase levels and liver hydroxyproline content in a dose-dependent manner.
Downregulated protein expression of fibronectin, type I collagen and α-smooth muscle actin in the liver in a dose-dependent manner.
Achieved therapeutic effect equivalent to 200 mg/kg pirfenidone at 20 mg/kg dose.
Masse moléculaire

628.84

Formule

C37H56O8
CAS No.
SMILES

CCCCCCCCCCCC(O[C@@]12[C@@]([C@@]3([H])[C@]([C@@H]([C@H]2OC(/C(C)=C/C)=O)C)([C@@]4([H])[C@](CC(CO)=C3)(C(C(C)=C4)=O)O)O)([H])C1(C)C)=O
Structure Classification
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

12-O-Tiglyl-phorbol 13-dodecanoate Related Classifications

  • Calculateur de molarité

  • Calculateur de dilution

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

12-O-Tiglyl-phorbol 13-dodecanoate37394-32-4Collagencarbon tetrachloridefibronectintype I collagenLX-2 cellsliver fibrosismiceTGF-β1hepatic stellate cellsα-smooth muscle actinEuphorbia fischerianaInhibitorinhibitorinhibit

Vos produits récemment consultés:

Demande en ligne

Your information is safe with us. * Required Fields.

Nom du produit

  

Requested Quantity *

Nom du demandeur *

 

Civilité

Adresse e-mail *

 

Numéro de téléphone *

Department

 

Nom de l'organisation *

City

État

Country or Region *

      

Remarques

Bulk Inquiry

Inquiry Information

Nom du produit:
12-O-Tiglyl-phorbol 13-dodecanoate
Cat. No.:
HY-N11736
Quantité:
MCE Japan Authorized Agent:

Avis client

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Nom du produit

  

Lot #

Nom du demandeur *

 

Adresse e-mail *

Numéro de téléphone

 

Department *

Nom de l'organisation *

 

Country or Region *

Remarques

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.