2. Cytoskeleton
  3. Collagen
  4. 12-O-Tiglyl-phorbol 13-dodecanoate

12-O-Tiglyl-phorbol 13-dodecanoate (TD13) is a potential inhibitor with anti-hepatic fibrosis activity, and it belongs to a series of derivatives of oral APOL2 inhibitors and anti-hepatic fibrosis agents. It shows no obvious toxicity in preclinical models. Compounds of the 12-O-Tiglyl-phorbol 13-dodecanoate series inhibit the expression of fibronectin, type I collagen and α-smooth muscle actin in hepatic stellate cells. 12-O-Tiglyl-phorbol 13-dodecanoate can be isolated from the Euphorbiaceae plant Euphorbia fischeriana, and it is applicable to the research of hepatic fibrosis.

For research use only. We do not sell to patients.

12-O-Tiglyl-phorbol 13-dodecanoate

12-O-Tiglyl-phorbol 13-dodecanoate Chemical Structure

CAS No. : 37394-32-4

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12-O-Tiglyl-phorbol 13-dodecanoate Related Antibodies

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Description

12-O-Tiglyl-phorbol 13-dodecanoate (TD13) is a potential inhibitor with anti-hepatic fibrosis activity, and it belongs to a series of derivatives of oral APOL2 inhibitors and anti-hepatic fibrosis agents. It shows no obvious toxicity in preclinical models. Compounds of the 12-O-Tiglyl-phorbol 13-dodecanoate series inhibit the expression of fibronectin, type I collagen and α-smooth muscle actin in hepatic stellate cells. 12-O-Tiglyl-phorbol 13-dodecanoate can be isolated from the Euphorbiaceae plant Euphorbia fischeriana, and it is applicable to the research of hepatic fibrosis[1].

IC50 & Target[1]

Collagen I

 

In Vitro

The 12-O-Tiglyl-phorbol 13-dodecanoate homologue TD1 (10 μM; 48 h) significantly inhibits fibronectin expression in TGF-β1-stimulated LX-2 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

12-O-Tiglyl-phorbol 13-dodecanoate Related Antibodies
In Vivo

The 12-O-Tiglyl-phorbol 13-dodecanoate analog TD1 (5-20 mg/kg; p.o.; once every 2 days; 5 w) dose-dependently ameliorates carbon tetrachloride (HY-Y0298)-induced liver fibrosis in mice, with the efficacy at the 20 mg/kg dose comparable to that of 200 mg/kg Pirfenidone (HY-B0673)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J mice with Liver fibrosis (8-week-old male, carbon tetrachloride-induced liver fibrosis)[1]
Dosage: 12-O-Tiglyl-phorbol 13-dodecanoate analog TD1:
5 mg/kg; 10 mg/kg; 20 mg/kg
Administration: p.o.; once every 2 days; 5 weeks
Result: Reduced liver inflammatory cell infiltration and fibrous proliferation in a dose-dependent manner.
Decreased serum alanine aminotransferase, aspartate aminotransferase levels and liver hydroxyproline content in a dose-dependent manner.
Downregulated protein expression of fibronectin, type I collagen and α-smooth muscle actin in the liver in a dose-dependent manner.
Achieved therapeutic effect equivalent to 200 mg/kg pirfenidone at 20 mg/kg dose.
Molecular Weight

628.84

Formula

C37H56O8
CAS No.
SMILES

CCCCCCCCCCCC(O[C@@]12[C@@]([C@@]3([H])[C@]([C@@H]([C@H]2OC(/C(C)=C/C)=O)C)([C@@]4([H])[C@](CC(CO)=C3)(C(C(C)=C4)=O)O)O)([H])C1(C)C)=O
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

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References
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12-O-Tiglyl-phorbol 13-dodecanoate Related Classifications

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Keywords:

12-O-Tiglyl-phorbol 13-dodecanoate37394-32-4Collagencarbon tetrachloridefibronectintype I collagenLX-2 cellsliver fibrosismiceTGF-β1hepatic stellate cellsα-smooth muscle actinEuphorbia fischerianaInhibitorinhibitorinhibit

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