13-cis-β-Carotene  (Synonyms: (7Z)-Provitamin A; (7Z)-beta-Carotene)

13-cis-β-Carotene ((7Z)-Provitamin A; (7Z)-beta-Carotene) is a provitamin A carotenoid isomer found in leaves, flowers, stems, and fruit of Momordica charantia. 13-cis-β-Carotene undergoes nonenzymatic isomerization to other β-carotene isomers during aerobic incubation, extraction, and analysis. 13-cis-β-Carotene can be used for the research of chronic diseases^[1][2].

13-cis-β-Carotene (15 μM; 60 min) is oxidatively cleaved by rat liver cytosolic enzyme preparations to produce 18.5 pmol total retinal per mg protein, with all-trans retinal as the predominant isomer, and exhibits a cleavage rate 8.3% that of all-trans-β-carotene^[2].
13-cis-β-Carotene (15 μM; 60 min) is oxidatively cleaved by rat intestinal mucosal enzyme preparations to produce 10 pmol all-trans retinal per mg protein, and exhibits a cleavage rate 1.8% that of all-trans-β-carotene^[2].
13-cis-β-Carotene (75 μM; 60 min) undergoes nonenzymatic isomerization in incubation medium to form other β-carotene isomers, with 3.9% of the substrate converted, predominantly to all-trans-β-carotene^[2].
13-cis-β-Carotene (75 μM; 60 min) has its nonenzymatic isomerization reduced by rat liver cytosolic enzyme preparations, resulting in 2.5% conversion to other β-carotene isomers, predominantly all-trans-β-carotene^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

536.89

C₄₀H₅₆

6811-73-0

C(=C/C(=C/C=C/C(=C\C=C\C=C(\C=C\C=C(\C=C\C=1C(C)(C)CCCC1C)/C)/C)/C)/C)\C=2C(C)(C)CCCC2C

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• [1]. Cuong DM, et al. Medically important carotenoids from Momordica charantia and their gene expressions in different organs. Saudi J Biol Sci. 2017 Dec;24(8):1913-1919.

  [2]. Nagao A, et al. Enzymatic formation of 9-cis, 13-cis, and all-trans retinals from isomers of beta-carotene. FASEB J. 1994;8(12):968-973.