2-Linoleoyl glycerol (Synonyms: 2-Monolinolein; 2-Monolinoleoylglycerol)

Art. -Nr.: HY-130311 Reinheit: 99.9%: Data Sheet
COA

SDS
Handling Instructions
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2-Linoleoyl glycerol (2-Monolinolein) is a partial CB1 receptor agonist with a pEC₅₀ of 4.781. 2-Linoleoyl glycerol activates the hCB1 receptor. 2-Linoleoyl glycerol does not induce an increase in intracellular free Ca²⁺. 2-Linoleoyl glycerol can be used in the research of neurological disorders.

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2-Linoleoyl glycerol Chemische Struktur

CAS. Nr. : 3443-82-1

Größe	Verfügbarkeit	Menge
Solvent
500 μg (14.10 mM * 100 μL in Methyl acetate)	Auf Lager	Estimated Time of Arrival: December 31
Solvent
1 mg (14.10 mM * 200 μL in Methyl acetate)	Auf Lager	Estimated Time of Arrival: December 31

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Other Forms of 2-Linoleoyl glycerol:

2-Linoleoyl glycerol-d₅ Angebot einholen

Spezialitätsempfehlungen

•Related Small Molecules:

•Related Proteins:

Alle Cannabinoid Receptor Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

CB1 CB2

Biologische Aktivität
Reinheit & Dokumentation
Verweise
Kundenbewertung

Beschreibung

IC₅₀ & Target^[1]

CB1R

4.781 (pEC₅₀)

In Vitro

2-Linoleoyl glycerol (1-50 μM; 4 h) acts as a low-affinity partial agonist of the CB1 receptor in Tango CNR1-bla U2OS cells, with a pEC₅₀ value of 4.781. Its CB1-dependent activity is potentiated by JZL195 and completely inhibited by AM251^[1].
2-Linoleoyl glycerol (10 μM) does not induce an increase in intracellular free calcium levels in NG108-15 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molekulargewicht

354.52

Formel

C₂₁H₃₈O₄

CAS. Nr.

3443-82-1

Appearance

Liquid

Color

Colorless to light yellow

SMILES

CCCCC/C=C\C/C=C\CCCCCCCC(OC(CO)CO)=O

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Solution, -20°C, 2 years

Reinheit & Dokumentation

Purity: 99.9%

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Data Sheet (262 KB) SDS (605 KB)

COA (238 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Lu L, et al. 2-Linoleoylglycerol Is a Partial Agonist of the Human Cannabinoid Type 1 Receptor that Can Suppress 2-Arachidonolyglycerol and Anandamide Activity. Cannabis Cannabinoid Res. 2019;4(4):231-239. Published 2019 Dec 9. [Content Brief]

[2]. Sugiura T, et al. 2-Arachidonoylglycerol, a putative endogenous cannabinoid receptor ligand, induces rapid, transient elevation of intracellular free Ca2+ in neuroblastoma x glioma hybrid NG108-15 cells. Biochem Biophys Res Commun. 1996;229(1):58-64. [Content Brief]

2-Linoleoyl glycerol Related Classifications

Neurological Disease

Molaritätsrechner
Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Diese Gleichung wird häufig abgekürzt als: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-Linoleoyl glycerol3443-82-12-Monolinolein 2-MonolinoleoylglycerolCannabinoid ReceptorCannabinoid Type 1 (CB1) receptor2-arachidonoylglycerolTango CNR1-bla U2OS cellsmonoacylglycerol hydrolysis inhibitorshuman CB1 receptorsanandamideNG108-15 cellsCB1 antagonistscannabidiolInhibitorinhibitorinhibit

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