3443-82-1
3443-82-1
Chemical Structure
2-Linoleoyl glycerol
Synonym(s): 2-Monolinolein; 2-Monolinoleoylglycerol
- CAS No.: 3443-82-1
- Formula:C21H38O4
- Molecular Weight:354.52
IUPAC Name: 1,3-dihydroxypropan-2-yl (9Z,12Z)-octadeca-9,12-dienoate
InChIKey: IEPGNWMPIFDNSD-HZJYTTRNSA-N
SMILES: CCCCC/C=C\C/C=C\CCCCCCCC(OC(CO)CO)=O
Biological Activity: 2-Linoleoyl glycerol (2-Monolinolein) is a partial CB1 receptor agonist with a pEC50 of 4.781. 2-Linoleoyl glycerol activates the hCB1 receptor. 2-Linoleoyl glycerol does not induce an increase in intracellular free Ca2+. 2-Linoleoyl glycerol can be used in the research of neurological disorders[1][2].
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2-Linoleoyl glycerol | 99.9% | 2-Linoleoyl glycerol (2-Monolinolein) is a partial CB1 receptor agonist with a pEC50 of 4.781. 2-Linoleoyl glycerol activates the hCB1 receptor. 2-Linoleoyl glycerol does not induce an increase in intracellular free Ca2+. 2-Linoleoyl glycerol can be used in the research of neurological disorders. | ||||||||||||||||||||
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2-Linoleoyl glycerol-d5 | 2-Linoleoyl glycerol-d5 (2-Monolinolein-d5; 2-Monolinoleoylglycerol-d5) is the deuterium labeled 2-Linoleoyl glycerol (HY-130311). 2-Linoleoyl glycerol (2-Monolinolein; 2-Monolinoleoylglycerol) is a monoacylglycerol that is an antagonist and partial agonist at the type 1 cannabinoid CB1 receptor. The potency of 2-Linoleoyl glycerol can be enhanced by JZL195 (HY-15250), an inhibitor of FAAH and MAGL, and inhibited by the CB1 antagonist AM251 (HY-15443) and Cannabidiol. As a CB1 antagonist, 2-Linoleoyl glycerol does not enhance, but only attenuates, the activity of the CB1/CB2 receptor ligands cannabinoids (AEA) and 2-arachidonoylglycerol (2-AG). | |||||||||||||||||||||
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References
- [1]. Lu L, et al. 2-Linoleoylglycerol Is a Partial Agonist of the Human Cannabinoid Type 1 Receptor that Can Suppress 2-Arachidonolyglycerol and Anandamide Activity. Cannabis Cannabinoid Res. 2019;4(4):231-239. Published 2019 Dec 9. [Content Brief]
- [2]. Sugiura T, et al. 2-Arachidonoylglycerol, a putative endogenous cannabinoid receptor ligand, induces rapid, transient elevation of intracellular free Ca2+ in neuroblastoma x glioma hybrid NG108-15 cells. Biochem Biophys Res Commun. 1996;229(1):58-64. [Content Brief]
