2-Linoleoyl glycerol
Based on 1 Customer Validation
2-Linoleoyl glycerol (2-Monolinolein) is a partial CB1 receptor agonist with a pEC50 of 4.781. 2-Linoleoyl glycerol activates the hCB1 receptor. 2-Linoleoyl glycerol does not induce an increase in intracellular free Ca2+. 2-Linoleoyl glycerol can be used in the research of neurological disorders.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.9%
- No. CAS: 3443-82-1
- Fòrmula: C21H38O4
- Peso molecular:354.52
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Almacenamiento:
Solution, -20°C, 2 years
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Actividad biológica
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Chemical Information
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- Referencias
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Help & FAQs
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HY-W011121
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
CB1R 4.781 (pEC50) |
In Vitro
2-Linoleoyl glycerol (1-50 μM; 4 h) acts as a low-affinity partial agonist of the CB1 receptor in Tango CNR1-bla U2OS cells, with a pEC50 value of 4.781. Its CB1-dependent activity is potentiated by JZL195 and completely inhibited by AM251[1].
2-Linoleoyl glycerol (10 μM) does not induce an increase in intracellular free calcium levels in NG108-15 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 3443-82-1
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Appearance Liquid
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Peso molecular 354.52
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Fòrmula C21H38O4
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Color Colorless to light yellow
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SMILES
CCCCC/C=C\C/C=C\CCCCCCCC(OC(CO)CO)=O
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Synonyms
2-Monolinolein; 2-Monolinoleoylglycerol
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Solution, -20°C, 2 years
Pureza y Documentación
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Ficha de datos (262 KB)
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SDS (605 KB)
- English - EN (605 KB)
- Français - FR (605 KB)
- Deutsch - DE (605 KB)
- Norwegian - NO (605 KB)
- Español - ES (605 KB)
- Swedish - SV (605 KB)
- Italian - IT (605 KB)
- Korean - KR (605 KB)
- Portuguese - PT (605 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Lu L, et al. 2-Linoleoylglycerol Is a Partial Agonist of the Human Cannabinoid Type 1 Receptor that Can Suppress 2-Arachidonolyglycerol and Anandamide Activity. Cannabis Cannabinoid Res. 2019;4(4):231-239. Published 2019 Dec 9. [Content Brief]
[2]. Sugiura T, et al. 2-Arachidonoylglycerol, a putative endogenous cannabinoid receptor ligand, induces rapid, transient elevation of intracellular free Ca2+ in neuroblastoma x glioma hybrid NG108-15 cells. Biochem Biophys Res Commun. 1996;229(1):58-64. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
2-Linoleoyl glycerol Related Classifications
HY-130311 Related Classifications
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