2-Linoleoyl glycerol  (Synonyms: 2-Monolinolein; 2-Monolinoleoylglycerol)

2-Linoleoyl glycerol (2-Monolinolein) is a partial CB1 receptor agonist with a pEC₅₀ of 4.781. 2-Linoleoyl glycerol activates the hCB1 receptor. 2-Linoleoyl glycerol does not induce an increase in intracellular free Ca²⁺. 2-Linoleoyl glycerol can be used in the research of neurological disorders^[1][2].

2-Linoleoyl glycerol (1-50 μM; 4 h) acts as a low-affinity partial agonist of the CB1 receptor in Tango CNR1-bla U2OS cells, with a pEC₅₀ value of 4.781. Its CB1-dependent activity is potentiated by JZL195 and completely inhibited by AM251^[1].
2-Linoleoyl glycerol (10 μM) does not induce an increase in intracellular free calcium levels in NG108-15 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

354.52

C₂₁H₃₈O₄

3443-82-1

Liquid

Colorless to light yellow

CCCCC/C=C\C/C=C\CCCCCCCC(OC(CO)CO)=O

Room temperature in continental US; may vary elsewhere.

Solution, -20°C, 2 years

• [1]. Lu L, et al. 2-Linoleoylglycerol Is a Partial Agonist of the Human Cannabinoid Type 1 Receptor that Can Suppress 2-Arachidonolyglycerol and Anandamide Activity. Cannabis Cannabinoid Res. 2019;4(4):231-239. Published 2019 Dec 9.  [Content Brief]

  [2]. Sugiura T, et al. 2-Arachidonoylglycerol, a putative endogenous cannabinoid receptor ligand, induces rapid, transient elevation of intracellular free Ca2+ in neuroblastoma x glioma hybrid NG108-15 cells. Biochem Biophys Res Commun. 1996;229(1):58-64.  [Content Brief]