2. GPCR/G Protein Neuronal Signaling
  3. Cannabinoid Receptor
  4. 2-Palmitoylglycerol

2-Palmitoylglycerol  (Synonyms: 2-Palm-Gl)

Cat. No.: HY-W013788 Purity: ≥99.0%
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2-Palmitoylglycerol (2-Palm-Gl), an congener of 2-arachidonoylglycerol (2-AG), is a modest cannabinoid receptor CB1 agonist. 2-Palmitoylglycerol also may be an endogenous ligand for GPR119.

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2-Palmitoylglycerol Chemical Structure

2-Palmitoylglycerol Chemical Structure

CAS No. : 23470-00-0

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Based on 1 publication(s) in Google Scholar

2-Palmitoylglycerol Related Antibodies

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Description

2-Palmitoylglycerol (2-Palm-Gl), an congener of 2-arachidonoylglycerol (2-AG), is a modest cannabinoid receptor CB1 agonist. 2-Palmitoylglycerol also may be an endogenous ligand for GPR119[1].

IC50 & Target

CB1

 

In Vitro

2-Palmitoylglycerol (2-PG) modestly internalizes CB1 receptor on its own at concentrations as low as 300nM. 2-Palmitoylglycerol behaves as a very modest antagonist in depolarization-induced suppression of excitation (DSE)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2-Palmitoylglycerol Related Antibodies
Molecular Weight

330.50

Formula

C19H38O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCCCCCCCCCC(OC(CO)CO)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (151.29 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0257 mL 15.1286 mL 30.2572 mL
5 mM 0.6051 mL 3.0257 mL 6.0514 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0257 mL 15.1286 mL 30.2572 mL 75.6430 mL
5 mM 0.6051 mL 3.0257 mL 6.0514 mL 15.1286 mL
10 mM 0.3026 mL 1.5129 mL 3.0257 mL 7.5643 mL
15 mM 0.2017 mL 1.0086 mL 2.0171 mL 5.0429 mL
20 mM 0.1513 mL 0.7564 mL 1.5129 mL 3.7821 mL
25 mM 0.1210 mL 0.6051 mL 1.2103 mL 3.0257 mL
30 mM 0.1009 mL 0.5043 mL 1.0086 mL 2.5214 mL
40 mM 0.0756 mL 0.3782 mL 0.7564 mL 1.8911 mL
50 mM 0.0605 mL 0.3026 mL 0.6051 mL 1.5129 mL
60 mM 0.0504 mL 0.2521 mL 0.5043 mL 1.2607 mL
80 mM 0.0378 mL 0.1891 mL 0.3782 mL 0.9455 mL
100 mM 0.0303 mL 0.1513 mL 0.3026 mL 0.7564 mL
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2-Palmitoylglycerol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-Palmitoylglycerol23470-00-02-Palm-GlCannabinoid ReceptorentouragecannabinoidCB12-arachidonoylglycerol2-palmitoyglycerol2-AG2-PGacylglycerolcongenerInhibitorinhibitorinhibit

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