1. GPCR/G Protein
  2. Cannabinoid Receptor

GW842166X 

Cat. No.: HY-14167 Purity: 99.97%
Handling Instructions

GW842166X is a potent and selective cannabinoid receptor 2 (CB2) agonist with IC50 values of 63 and 91 nM for human and rat CB2, respectively.

For research use only. We do not sell to patients.

GW842166X Chemical Structure

GW842166X Chemical Structure

CAS No. : 666260-75-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 79 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
2 mg USD 50 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
5 mg USD 80 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
10 mg USD 140 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
25 mg USD 260 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

GW842166X is a potent and selective cannabinoid receptor 2 (CB2) agonist with IC50 values of 63 and 91 nM for human and rat CB2, respectively.

IC50 & Target

IC50: 63 nM (human CB2), 91 nM (rat CB2)[1]

In Vitro

GW842166X shows similar potency and efficacy for rat and human recombinant CB2 receptors. It has no significant agonist activity at concentrations up to 30 µM in human and rat CB1 recombinant assays[1].

In Vivo

GW842166X has an oral ED50 of 0.1 mg/kg in the rat FCA model of inflammatory pain and shows full reversal of hyperalgesia at 0.3 mg/kg. The blood concentrations of GW842166X in experiments are 30 nM (0.03 mg/kg), 130 nM (0.1 mg/kg), and 370 nM (0.3 mg/ kg) 1 h after dosing. After dosing for 4 days in the FCA model, no statistical difference in antihyperalgesic response is observed on day 4 relative to day 1, indicating that tolerance does not occur[1].

Clinical Trial
References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.2259 mL 11.1297 mL 22.2593 mL
5 mM 0.4452 mL 2.2259 mL 4.4519 mL
10 mM 0.2226 mL 1.1130 mL 2.2259 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

449.25

Formula

C₁₈H₁₇Cl₂F₃N₄O₂

CAS No.

666260-75-9

SMILES

ClC1=CC(Cl)=C(NC2=NC=C(C(NCC3CCOCC3)=O)C(C(F)(F)F)=N2)C=C1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥83.3 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 99.97%

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Inquiry Information

Product Name:
GW842166X
Cat. No.:
HY-14167
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