1. GPCR/G Protein Neuronal Signaling Anti-infection
  2. Cannabinoid Receptor Bacterial
  3. Rimonabant

Rimonabant  (Synonyms: SR141716)

Cat. No.: HY-14136 Purity: 99.41%
COA Handling Instructions

Rimonabant (SR141716) is a highly potent, brain penetrated and selective central cannabinoid receptor (CB1) antagonist with a Ki of 1.8 nM. Rimonabant (SR141716) also inhibits Mycobacterial membrane protein Large 3 (MMPL3).

For research use only. We do not sell to patients.

Rimonabant Chemical Structure

Rimonabant Chemical Structure

CAS No. : 168273-06-1

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Based on 5 publication(s) in Google Scholar

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Description

Rimonabant (SR141716) is a highly potent, brain penetrated and selective central cannabinoid receptor (CB1) antagonist with a Ki of 1.8 nM. Rimonabant (SR141716) also inhibits Mycobacterial membrane protein Large 3 (MMPL3).

IC50 & Target[1]

CB1

1.8 nM (Ki)

In Vitro

Rimonabant could inhibit the growth of Mtb with an MIC of 54 μM. MmpL3, an anti-TB target, is the direct target of rimonabant[2].
Rimonabant itself (10-12-10-3 M, 12 concentrations) inhibits the basal binding of [35S]GTPgS to human cortical membranes in a concentration dependent manner, with a -log IC50 of 4.7±0.2 (IC50 = 20 μM) and a maximal inhibition of 48±2%[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Rimonabant (10 mg/kg by gavage) is fed for 2 weeks to 3-month-old male obese Zucker rats as an impaired glucose tolerance model and for 10 weeks to 6-month-old male obese Zucker rats as a model of the metabolic syndrome. RANTES and MCP-1 serum levels are increased in obese vs lean Zucker rats and significantly reduced by long-term treatment with Rimonabant, which slowes weight gain in rats with the metabolic syndrome. Neutrophils and monocytes are significantly increased in young and old obese vs lean Zucker rats and lowered by Rimonabant. Platelet-bound fibrinogen is significantly enhanced in obese vs lean Zucker rats of both age, and is reduced by Rimonabant [1].
Rimonabant (20 mg daily) exhibits a significant reduction in many cardiometabolic risk factors[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

463.79

Formula

C22H21Cl3N4O

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

ClC1=CC=C(C=C1)C2=C(C(C(NN3CCCCC3)=O)=NN2C4=CC=C(C=C4Cl)Cl)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (269.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1561 mL 10.7807 mL 21.5615 mL
5 mM 0.4312 mL 2.1561 mL 4.3123 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1561 mL 10.7807 mL 21.5615 mL 53.9037 mL
5 mM 0.4312 mL 2.1561 mL 4.3123 mL 10.7807 mL
10 mM 0.2156 mL 1.0781 mL 2.1561 mL 5.3904 mL
15 mM 0.1437 mL 0.7187 mL 1.4374 mL 3.5936 mL
20 mM 0.1078 mL 0.5390 mL 1.0781 mL 2.6952 mL
25 mM 0.0862 mL 0.4312 mL 0.8625 mL 2.1561 mL
30 mM 0.0719 mL 0.3594 mL 0.7187 mL 1.7968 mL
40 mM 0.0539 mL 0.2695 mL 0.5390 mL 1.3476 mL
50 mM 0.0431 mL 0.2156 mL 0.4312 mL 1.0781 mL
60 mM 0.0359 mL 0.1797 mL 0.3594 mL 0.8984 mL
80 mM 0.0270 mL 0.1348 mL 0.2695 mL 0.6738 mL
100 mM 0.0216 mL 0.1078 mL 0.2156 mL 0.5390 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Rimonabant
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