1. GPCR/G Protein
    Autophagy
    Anti-infection
  2. Cannabinoid Receptor
    Autophagy
    Bacterial

Rimonabant Hydrochloride (Synonyms: SR 141716A; SR 151716A)

Cat. No.: HY-14137 Purity: 99.08%
Handling Instructions

Rimonabant hydrochloride is a highly potent and selective central cannabinoid (CB1) receptor inverse agonist with an Ki of 1.8 nM. Rimonabant hydrochloride also inhibits Mycobacterial membrane protein Large 3 (MMPL3).

For research use only. We do not sell to patients.

Rimonabant Hydrochloride Chemical Structure

Rimonabant Hydrochloride Chemical Structure

CAS No. : 158681-13-1

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 77 In-stock
Estimated Time of Arrival: December 31
10 mg USD 70 In-stock
Estimated Time of Arrival: December 31
50 mg USD 240 In-stock
Estimated Time of Arrival: December 31
100 mg USD 360 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Other Forms of Rimonabant Hydrochloride:

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Rimonabant hydrochloride is a highly potent and selective central cannabinoid (CB1) receptor inverse agonist with an Ki of 1.8 nM. Rimonabant hydrochloride also inhibits Mycobacterial membrane protein Large 3 (MMPL3).

IC50 & Target

Ki: 1.8 nM(CB1 Receptor)[1]. MMPL3[2].

In Vitro

Rimonabant could inhibit the growth of Mtb with an MIC of 54 μM. MmpL3, an anti-TB target, is the direct target of rimonabant[2].
Rimonabant itself (10-12-10-3 M, 12 concentrations) inhibits the basal binding of [35S]GTPgS to human cortical membranes in a concentration dependent manner, with a -log IC50 of 4.7±0.2 (IC50 = 20 μM) and a maximal inhibition of 48±2%[3].

In Vivo

Rimonabant (10 mg/kg by gavage) is fed for 2 weeks to 3-month-old male obese Zucker rats as an impaired glucose tolerance model and for 10 weeks to 6-month-old male obese Zucker rats as a model of the metabolic syndrome. RANTES and MCP-1 serum levels are increased in obese vs lean Zucker rats and significantly reduced by long-term treatment with Rimonabant, which slowes weight gain in rats with the metabolic syndrome. Neutrophils and monocytes are significantly increased in young and old obese vs lean Zucker rats and lowered by Rimonabant. Platelet-bound fibrinogen is significantly enhanced in obese vs lean Zucker rats of both age, and is reduced by Rimonabant [1].
Rimonabant (20 mg daily) exhibits a significant reduction in many cardiometabolic risk factors[4].

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (66.63 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9990 mL 9.9950 mL 19.9900 mL
5 mM 0.3998 mL 1.9990 mL 3.9980 mL
10 mM 0.1999 mL 0.9995 mL 1.9990 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.00 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (5.00 mM); Suspended solution; Need ultrasonic

References
Molecular Weight

500.25

Formula

C₂₂H₂₂Cl₄N₄O

CAS No.

158681-13-1

SMILES

ClC1=CC=C(C2=C(C)C(C(NN3CCCCC3)=O)=NN2C4=CC=C(Cl)C=C4Cl)C=C1.Cl

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Rimonabant Hydrochloride
Cat. No.:
HY-14137
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Rimonabant Hydrochloride

Cat. No.: HY-14137