Discovery of indole alkaloids with cannabinoid CB1 receptor antagonistic activity

  • Bioorg Med Chem Lett. 2011 Apr 1;21(7):1962-4. doi: 10.1016/j.bmcl.2011.02.036.
Mariko Kitajima  1 ,  Masumi Iwai ,  Ruri Kikura-Hanajiri ,  Yukihiro Goda ,  Mitsuru Iida ,  Hisatoshi Yabushita ,  Hiromitsu Takayama
Affiliations
  • 1. Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.
PMID: 21376588 DOI: 10.1016/j.bmcl.2011.02.036
Abstract

Three Indole Alkaloids, voacamine (1), 3,6-oxidovoacangine (2), and a new alkaloid, 5-hydroxy-3,6-oxidovoacangine (3), isolated from Voacanga africana were found to exhibit potent cannabinoid CB1 receptor antagonistic activity. This is the first example of CB1 antagonists derived from natural Alkaloids.

Products