1. GPCR/G Protein
    Neuronal Signaling
  2. Cannabinoid Receptor
  3. JD-5037

JD-5037 

Cat. No.: HY-18697 Purity: 98.77%
Handling Instructions

JD-5037 is a potent CB1R antagonist with an IC50 of 1.5 nM.

For research use only. We do not sell to patients.

JD-5037 Chemical Structure

JD-5037 Chemical Structure

CAS No. : 1392116-14-1

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 136 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 136 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 108 In-stock
Estimated Time of Arrival: December 31
10 mg USD 192 In-stock
Estimated Time of Arrival: December 31
50 mg USD 588 In-stock
Estimated Time of Arrival: December 31
100 mg USD 828 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 6 publication(s) in Google Scholar

Top Publications Citing Use of Products

    JD-5037 purchased from MCE. Usage Cited in: J Am Soc Nephrol. 2017 Dec;28(12):3518-3532.

    The peripheral blockade of CB1R by JD5037 (3 mg/kg, administered orally) significantly normalizes the expression levels of pLKB1.

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    Description

    JD-5037 is a potent CB1R antagonist with an IC50 of 1.5 nM.

    IC50 & Target

    CB1

    1.5 nM (IC50)

    In Vivo

    JD5037 (3 mg/kg/d, i.p.) induces equal reductions in body weight, attenuates the HFD-induced hyperglycemia, and reduces the HFD-induced hepatic injury and steatosis in obese Magel2-null mice[2]. JD5037 (3 mg/kg/day, p.o.) significantly reduces the size of tumors and abrogates the tumor in DEN-treated mice. JD5037 attenuates the AEA levels in HCC samples from mice[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Molecular Weight

    572.51

    Formula

    C₂₇H₂₇Cl₂N₅O₃S

    CAS No.
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 100 mg/mL (174.67 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.7467 mL 8.7335 mL 17.4669 mL
    5 mM 0.3493 mL 1.7467 mL 3.4934 mL
    10 mM 0.1747 mL 0.8733 mL 1.7467 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.75 mg/mL (4.80 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.75 mg/mL (4.80 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
    Animal Administration
    [2]

    Mice: JD-5037 is formulated in vehicle (V; 1% Tween80, 4% DMSO, 95% Saline). Obese mice are treated chronically (28 d) with vehicle (V; 1% Tween80, 4% DMSO, 95% Saline), JD5037, or SLV319 at a dose of 3 mg/kg, i.p. Body weight and food intake are monitored daily. Mice are euthanized by cervical dislocation under anesthesia; the brain, hypothalamus, liver, and combined fat pads are removed, weighed, and snap-frozen, and trunk blood is collected for determining the endocrine and biochemical parameters[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    References

    Purity: 98.77%

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    Product Name:
    JD-5037
    Cat. No.:
    HY-18697
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