1. GPCR/G Protein
  2. Cannabinoid Receptor

JD-5037 

Cat. No.: HY-18697 Purity: 98.05%
Handling Instructions

JD-5037 is a novel, peripherally restricted CB1R antagonist with an IC50 of 1.5 nM.

For research use only. We do not sell to patients.

JD-5037 Chemical Structure

JD-5037 Chemical Structure

CAS No. : 1392116-14-1

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 136 In-stock
Estimated Time of Arrival: December 31
5 mg USD 108 In-stock
Estimated Time of Arrival: December 31
10 mg USD 192 In-stock
Estimated Time of Arrival: December 31
50 mg USD 588 In-stock
Estimated Time of Arrival: December 31
100 mg USD 828 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

    JD-5037 purchased from MCE. Usage Cited in: J Am Soc Nephrol. 2017 Dec;28(12):3518-3532.

    The peripheral blockade of CB1R by JD5037 (3 mg/kg, administered orally) significantly normalizes the expression levels of pLKB1.
    • Biological Activity

    • Protocol

    • Technical Information

    • Purity & Documentation

    • References

    Description

    JD-5037 is a novel, peripherally restricted CB1R antagonist with an IC50 of 1.5 nM.

    IC50 & Target

    IC50: 1.5 nM (CB1R)[1]

    In Vivo

    JD5037 (3 mg/kg/d, i.p.) induces equal reductions in body weight, attenuates the HFD-induced hyperglycemia, and reduces the HFD-induced hepatic injury and steatosis in obese Magel2-null mice[2]. JD5037 (3 mg/kg/day, p.o.) significantly reduces the size of tumors and abrogates the tumor in DEN-treated mice. JD5037 attenuates the AEA levels in HCC samples from mice[3].

    Solvent & Solubility
    In Vitro: 

    10 mM in DMSO

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.7467 mL 8.7335 mL 17.4669 mL
    5 mM 0.3493 mL 1.7467 mL 3.4934 mL
    10 mM 0.1747 mL 0.8733 mL 1.7467 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
    Animal Administration
    [2]

    Mice: JD-5037 is formulated in vehicle (V; 1% Tween80, 4% DMSO, 95% Saline). Obese mice are treated chronically (28 d) with vehicle (V; 1% Tween80, 4% DMSO, 95% Saline), JD5037, or SLV319 at a dose of 3 mg/kg, i.p. Body weight and food intake are monitored daily. Mice are euthanized by cervical dislocation under anesthesia; the brain, hypothalamus, liver, and combined fat pads are removed, weighed, and snap-frozen, and trunk blood is collected for determining the endocrine and biochemical parameters[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    References
    Molecular Weight

    572.51

    Formula

    C₂₇H₂₇Cl₂N₅O₃S

    CAS No.

    1392116-14-1

    SMILES

    NC([[email protected]](C(C)C)/N=C(NS(=O)(C1=CC=C(Cl)C=C1)=O)\N2N=C(C3=CC=C(Cl)C=C3)[[email protected]@H](C4=CC=CC=C4)C2)=O

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

    Purity: 98.05%

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    Product Name:
    JD-5037
    Cat. No.:
    HY-18697
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    JD-5037

    Cat. No.: HY-18697