3,5-Bis(4-nitrophenoxy)benzoic acid

Art. -Nr.: HY-103539 Reinheit: 98.50%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

3,5-Bis(4-nitrophenoxy)benzoic acid is an inhibitor of γ-secretase. 3,5-Bis(4-nitrophenoxy)benzoic acid causes a decrease in the released levels of Aβ42 and notch-1 Aβ-like peptide 25 (Nβ25). 3,5-Bis(4-nitrophenoxy)benzoic acid, as a marker for fetal hypothyroidism, is a 3,3’-diiodothyronine sulfate (T2S) cross-reactive material in maternal serum.

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3,5-Bis(4-nitrophenoxy)benzoic acid Chemische Struktur

CAS. Nr. : 173550-33-9

Größe	Verfügbarkeit	Menge
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	Auf Lager	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	Auf Lager	Estimated Time of Arrival: December 31
Solid
25 mg	Auf Lager	Estimated Time of Arrival: December 31
50 mg	Auf Lager	Estimated Time of Arrival: December 31
100 mg	Auf Lager	Estimated Time of Arrival: December 31
250 mg	Auf Lager	Estimated Time of Arrival: December 31
500 mg	Angebot einholen
1 g	Angebot einholen

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Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biologische Aktivität
Reinheit & Dokumentation
Verweise
Kundenbewertung

Beschreibung

Molekulargewicht

396.31

Formel

C₁₉H₁₂N₂O₈

CAS. Nr.

173550-33-9

Appearance

Solid

Color

Light yellow to light brown

SMILES

O=C(O)C1=CC(OC2=CC=C([N+]([O-])=O)C=C2)=CC(OC3=CC=C([N+]([O-])=O)C=C3)=C1

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (252.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5233 mL	12.6164 mL	25.2328 mL
5 mM	0.5047 mL	2.5233 mL	5.0466 mL
10 mM	0.2523 mL	1.2616 mL	2.5233 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Reinheit & Dokumentation

Purity: 98.50%

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Data Sheet (272 KB) SDS (251 KB)

COA (246 KB) HNMR (266 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Wu SY, et al. Compound W, a 3,3'-diiodothyronine sulfate cross-reactive substance in serum from pregnant women--a potential marker for fetal thyroid function. Pediatr Res. 2007;61(3):307-312. [Content Brief]

[2]. Ran Y, et al. Differential Inhibition of Signal Peptide Peptidase Family Members by Established γ-Secretase Inhibitors. PLoS One. 2015;10(6):e0128619. Published 2015 Jun 5. [Content Brief]

[3]. Greife A, et al. Canonical Notch signalling is inactive in urothelial carcinoma. BMC Cancer. 2014;14:628. Published 2014 Aug 29. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5233 mL	12.6164 mL	25.2328 mL	63.0819 mL
	5 mM	0.5047 mL	2.5233 mL	5.0466 mL	12.6164 mL
	10 mM	0.2523 mL	1.2616 mL	2.5233 mL	6.3082 mL
	15 mM	0.1682 mL	0.8411 mL	1.6822 mL	4.2055 mL
	20 mM	0.1262 mL	0.6308 mL	1.2616 mL	3.1541 mL
	25 mM	0.1009 mL	0.5047 mL	1.0093 mL	2.5233 mL
	30 mM	0.0841 mL	0.4205 mL	0.8411 mL	2.1027 mL
	40 mM	0.0631 mL	0.3154 mL	0.6308 mL	1.5770 mL
	50 mM	0.0505 mL	0.2523 mL	0.5047 mL	1.2616 mL
	60 mM	0.0421 mL	0.2103 mL	0.4205 mL	1.0514 mL
	80 mM	0.0315 mL	0.1577 mL	0.3154 mL	0.7885 mL
	100 mM	0.0252 mL	0.1262 mL	0.2523 mL	0.6308 mL