2. Membrane Transporter/Ion Channel
  3. P2X Receptor
  4. BzATP triethylammonium

BzATP triethylammonium  (Synonyms: Benzoylbenzoyl-ATP triethylammonium)

Cat. No.: HY-18745
SDS
Handling Instructions Technical Support

BzATP triethylammonium acts as a P2X receptor agonist with pEC50s of 8.74, 5.26, 7.10, 7.50, 6.19, 6.31, 5.33 for P2X1, P2X2, P2X3, P2X2/3, P2X4 and P2X7, respectively. BzATP triethylammonium is potent at P2X7 receptors with EC50s of 3.6 μM and 285 μM for rat P2X7 and mouse P2X7, respectively.

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BzATP triethylammonium

BzATP triethylammonium 화학구조

CAS No. : 112898-15-4

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고객리뷰

Based on 1 publication(s) in Google Scholar

Other Forms of BzATP triethylammonium:

BzATP triethylammonium Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE BzATP triethylammonium

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P2X1 Receptor P2X2 Receptor P2X3 Receptor P2X4 Receptor P2X7 Receptor

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

BzATP triethylammonium acts as a P2X receptor agonist with pEC50s of 8.74, 5.26, 7.10, 7.50, 6.19, 6.31, 5.33 for P2X1, P2X2, P2X3, P2X2/3, P2X4 and P2X7, respectively[1]. BzATP triethylammonium is potent at P2X7 receptors with EC50s of 3.6 μM and 285 μM for rat P2X7 and mouse P2X7, respectively[2].

IC50 & Target

pEC50: 8.74 (P2X1), 5.26 (P2X2), 7.10 (P2X3), 6.19 (P2X2/3), 6.31 (P2X4), 5.33 (P2X7)[1]
EC50 3.6 μM (rat P2X7); 285 μM (mouse P2X7)[2]
In Vitro

BzATP (10-1000 μM; 24 h) triethylammonium promotes the proliferation and migration of U87 and U251 glioma cells[3].
[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BzATP triethylammonium Related Antibodies

Cell Proliferation Assay[3]

Cell Line: U87 and U251 glioma cells
Concentration: 5, 10, 50, 100, 500 and 1000 μM
Incubation Time: 2, 6, 12, 24, 48 and 72 hours
Result: The proliferation of U87 and U251 glioma cell lines was significantly increased in the presence of 10-1000 uM and 100-1000 μM, respectively.
The peak of cell proliferation of both U87 and U251 cell lines was at 100 μM.
The optimal incubation time is 24 hours in both U87 and U251 cells lines.

Western Blot Analysis[3]

Cell Line: U87 and U251 glioma cells
Concentration: 100 μM
Incubation Time: 6-48 hours
Result: Induced the upregulation of P2X7R.
In Vivo

BzATP (5 mg/kg) triethylammonium significantly promotes P2X7R expression in the intestines compared with intestines in the sham group and the control group after cecal ligation and puncture (CLP) induction[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male 2-month-old C57BL/6 mice (each weighing between 20 and 25 g)[4]
Dosage: 5 mg/kg
Administration: Injected through the intraperitoneal route
Result: At 48 hours, mice in the treated group and control group exhibited mortalities of 91% and 86%, respectively.
분자량

816.58

화학식

C30H39N6O15P3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NC1=C2C(N([C@@H]3O[C@H](COP(OP(OP(O)(O)=O)(O)=O)(O)=O)[C@@H](OC(C4=CC=C(C=C4)C(C5=CC=CC=C5)=O)=O)[C@H]3O)C=N2)=NC=N1.CCN(CC)CC
선적

Room temperature in continental US; may vary elsewhere.
보관

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

순도&문서
References
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BzATP triethylammonium Related Classifications

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  • 농도 희석 계산기

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BzATP112898-15-4Benzoylbenzoyl-ATPP2X ReceptorP2XRsP2X1P2X2P2X3P2X2/3P2X4P2X7inflammatoryOvarianCarcinomaInhibitorinhibitorinhibit

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BzATP triethylammonium
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HY-18745
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