112898-15-4
Chemical Structure
BzATP triethylammonium
Synonym(s): Benzoylbenzoyl-ATP triethylammonium
- CAS No.: 112898-15-4
- Formula:C30H39N6O15P3
- Molecular Weight:816.58
IUPAC Name: triethylamine ((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3-((4-benzoylbenzoyl)oxy)-4-hydroxytetrahydrofuran-2-yl)methyl triphosphate
InChIKey: HVOVBTNCGADRTH-WBLDMZOZSA-N
SMILES: NC1=C2C(N([C@@H]3O[C@H](COP(OP(OP(O)(O)=O)(O)=O)(O)=O)[C@@H](OC(C4=CC=C(C=C4)C(C5=CC=CC=C5)=O)=O)[C@H]3O)C=N2)=NC=N1.CCN(CC)CC
Biological Activity: BzATP triethylammonium acts as a P2X receptor agonist with pEC50s of 8.74, 5.26, 7.10, 7.50, 6.19, 6.31, 5.33 for P2X1, P2X2, P2X3, P2X2/3, P2X4 and P2X7, respectively[1]. BzATP triethylammonium is potent at P2X7 receptors with EC50s of 3.6 μM and 285 μM for rat P2X7 and mouse P2X7, respectively[2].
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BzATP triethylammonium | BzATP triethylammonium acts as a P2X receptor agonist with pEC50s of 8.74, 5.26, 7.10, 7.50, 6.19, 6.31, 5.33 for P2X1, P2X2, P2X3, P2X2/3, P2X4 and P2X7, respectively. BzATP triethylammonium is potent at P2X7 receptors with EC50s of 3.6 μM and 285 μM for rat P2X7 and mouse P2X7, respectively. | |||||||||||||||||||||
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- [1]. B R Bianchi, et al. Pharmacological characterization of recombinant human and rat P2X receptor subtypes. Eur J Pharmacol. 1999 Jul 2;376(1-2):127-38. [Content Brief]
- [2]. Mark T Young, et al. Amino acid residues in the P2X7 receptor that mediate differential sensitivity to ATP and BzATP. Mol Pharmacol. 2007 Jan;71(1):92-100. [Content Brief]
Keywords
