BzATP triethylammonium
Based on 1 publication(s) in Google Scholar
BzATP triethylammonium acts as a P2X receptor agonist with pEC50s of 8.74, 5.26, 7.10, 7.50, 6.19, 6.31, 5.33 for P2X1, P2X2, P2X3, P2X2/3, P2X4 and P2X7, respectively. BzATP triethylammonium is potent at P2X7 receptors with EC50s of 3.6 μM and 285 μM for rat P2X7 and mouse P2X7, respectively.
For research use only. We do not sell to patients.
- CAS No.: 112898-15-4
- Formula: C30H39N6O15P3
- Molecular Weight:816.58
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) BzATP triethylammonium
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Biological Activity
pEC50: 8.74 (P2X1), 5.26 (P2X2), 7.10 (P2X3), 6.19 (P2X2/3), 6.31 (P2X4), 5.33 (P2X7)[1]
EC50 3.6 μM (rat P2X7); 285 μM (mouse P2X7)[2]
BzATP (10-1000 μM; 24 h) triethylammonium promotes the proliferation and migration of U87 and U251 glioma cells[3].
[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:U87 and U251 glioma cells
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Concentration:5, 10, 50, 100, 500 and 1000 μM
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Incubation Time:2, 6, 12, 24, 48 and 72 hours
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Result:The proliferation of U87 and U251 glioma cell lines was significantly increased in the presence of 10-1000 uM and 100-1000 μM, respectively.
The peak of cell proliferation of both U87 and U251 cell lines was at 100 μM.
The optimal incubation time is 24 hours in both U87 and U251 cells lines.
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Cell Line:U87 and U251 glioma cells
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Concentration:100 μM
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Incubation Time:6-48 hours
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Result:Induced the upregulation of P2X7R.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male 2-month-old C57BL/6 mice (each weighing between 20 and 25 g)[4]
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Dosage:5 mg/kg
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Administration:Injected through the intraperitoneal route
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Result:At 48 hours, mice in the treated group and control group exhibited mortalities of 91% and 86%, respectively.
Chemical Information
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CAS No. 112898-15-4
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Appearance Solid
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Molecular Weight 816.58
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Formula C30H39N6O15P3
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Color White to off-white
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SMILES
NC1=C2C(N([C@@H]3O[C@H](COP(OP(OP(O)(O)=O)(O)=O)(O)=O)[C@@H](OC(C4=CC=C(C=C4)C(C5=CC=CC=C5)=O)=O)[C@H]3O)C=N2)=NC=N1.CCN(CC)CC
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Synonyms
Benzoylbenzoyl-ATP triethylammonium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Mol Med Rep
High glucose inhibits osteogenic differentiation and proliferation of MC3T3‑E1 cells by regulating P2X7. [Abstract]2019 Dec;20(6):5084-5090. PMID: 31702818
Purity & Documentation
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Data Sheet (281 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. B R Bianchi, et al. Pharmacological characterization of recombinant human and rat P2X receptor subtypes. Eur J Pharmacol. 1999 Jul 2;376(1-2):127-38. [Content Brief]
[2]. Mark T Young, et al. Amino acid residues in the P2X7 receptor that mediate differential sensitivity to ATP and BzATP. Mol Pharmacol. 2007 Jan;71(1):92-100. [Content Brief]
[3]. Zhenhua Ji, et al. Involvement of P2X 7 Receptor in Proliferation and Migration of Human Glioma Cells. Biomed Res Int. 2018 Jan 9;2018:8591397. [Content Brief]
[4]. Xiuwen Wu, et al. Systemic blockade of P2X7 receptor protects against sepsis-induced intestinal barrier disruption. Sci Rep. 2017 Jun 29;7(1):4364. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BzATP triethylammonium Related Classifications
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