7β-Hydroxy-epi-androsterone  (Synonyms: 7β-Hydroxy-EpiA)

7β-Hydroxy-epi-androsterone (7β-Hydroxy-EpiA) can bind to ERβ and has anti-inflammatory and neuroprotective properties. 7β-Hydroxy-epi-androsterone is an endogenous androgenic derivative of dehydroepiandrosterone^[1][2][3].

7β-Hydroxy-epi-androsterone (1, 10 and 100 nM, 72 h) inhibits MCF-7 and MDA-MB-231 cell proliferation in the presence of E2 (10 nM)^[2].
7β-Hydroxy-epi-androsterone (1, 10 and 100 nM, 48 h) leads to a G0/G1 cell cycle arrest in MCF-7 and MDA-MB-231 cells^[2].
7β-Hydroxy-epi-androsterone (1, 10 and 100 nM, 48 h) increases cell apoptosis in the presence of E2 (10 nM) in MCF-7 cells^[2].
7β-Hydroxy-epi-androsterone (1, 10 and 100 nM, 24 h) binds to ERβ and decreases in transactivation in MDA-MB-231 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

7β-Hydroxy-epi-androsterone (i.p., once a day for 7 days) displays anti-inflammatory effects in rat with DSS-induced colitis^[3].
7β-Hydroxy-epi-androsterone (0.1 mg/kg s.c., b.i.d. for 10 days) shows protective effect against inflammatory neurodegeneration and glial cell death in Alzheimer's disease rats^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

306.44

C₁₉H₃₀O₃

25848-69-5

C[C@@]12[C@]3([H])[C@]([C@@H](O)C[C@@]1([H])C[C@@H](O)CC2)([H])[C@@]4([H])[C@@](C)(C(CC4)=O)CC3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Christophe Ricco, et al. Synthesis of 7β-hydroxy-epiandrosterone. Steroids. Volume 76, Issues 1-2, January 2011, Pages 28-30.

  [2]. Sandra N, et al. The DHEA metabolite 7β-hydroxy-epiandrosterone exerts anti-estrogenic effects on breast cancer cell lines. Steroids. 2012 Apr;77(5):542-51.  [Content Brief]

  [3]. Hennebert O, et al. Anti-inflammatory effects and changes in prostaglandin patterns induced by 7beta-hydroxy-epiandrosterone in rats with colitis. J Steroid Biochem Mol Biol. 2008 Jun;110(3-5):255-62.  [Content Brief]

  [4]. Dudas B, et al. Protection against inflammatory neurodegeneration and glial cell death by 7beta-hydroxy epiandrosterone, a novel neurosteroid. Neurobiol Dis. 2004 Mar;15(2):262-8.  [Content Brief]