2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline

7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline (compound 11), a tetrahydroisoquinoline (THIQ) derivative, is a selective phenylethanolamine N-methyltransferase (PNMT) inhibitor with a Ki value of 0.3 μM. 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline can be used in research on psychiatric disorders related to Alzheimer's disease and Parkinson's disease.

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7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline

7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline Estructura química

No. CAS : 61563-24-4

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7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline Related Antibodies

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Descripciòn

7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline (compound 11), a tetrahydroisoquinoline (THIQ) derivative, is a selective phenylethanolamine N-methyltransferase (PNMT) inhibitor with a Ki value of 0.3 μM. 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline can be used in research on psychiatric disorders related to Alzheimer's disease and Parkinson's disease[1].

In Vivo

7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline (SKF-64139) (i.p., 40 mg/kg, once daily, 3 days) has an important role in the regulation of blood pressure and changes in adrenal catecholamine levels in rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male spontaneously hypertensive (SHR) and their age-paired normotensive Wistar-Kyoto (WKY) rats[2]
Dosage: 40 mg/kg
Administration: i.p.; once daily; 3 days
Result: Caused a decrease in blood pressure in SHR rats but no effect on blood pressure in WKY rats.
Caused a decrease in hypothalamic epinephrine (Epi) levels, norepinephrine (NE) levels and raised dopamine (DA) levels in both SHR and WKY rats.
Peso molecular

202.08

Fòrmula

C9H9Cl2N
No. CAS
SMILES

ClC1=C(Cl)C=CC2=C1CNCC2
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
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7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline Related Classifications

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Keywords:

7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline61563-24-4Endogenous MetabolitetetrahydroisoquinolineTHIQ derivativePNMTAlzheimer's diseaseParkinson's diseaseInhibitorinhibitorinhibit

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Nombre del producto:
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline
Cat. No.:
HY-113969
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