1. Metabolic Enzyme/Protease
  2. Elastase


Cat. No.: HY-19406
Handling Instructions

AE-3763 is a peptide-based human neutrophil elastase inhibitor with an IC50 of 29 nM.

For research use only. We do not sell to patients.

AE-3763 Chemical Structure

AE-3763 Chemical Structure

CAS No. : 291778-77-3

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References


AE-3763 is a peptide-based human neutrophil elastase inhibitor with an IC50 of 29 nM.

IC50 & Target

IC50: 29 nM (Human neutrophil elastase)[1]

In Vitro

AE-3763 exhibits potent in vitro inhibitory activity against human neutrophil elastase as well as extremely high solubility and stability in water[1].

In Vivo

Edema and leukocytes infiltration into the lung are significantly inhibited by infusion of AE-3763. AE3763 significantly improves survival rate by 24 h in a mouse model of fatal shock associated with multiple organ dysfunction. AE-3763 dose-dependently prevents hemorrhage when given intravenously by infusion (ED50: 0.42 mg/kg/h) or by bolus injection (1.2 mg/kg). With regard to the toxicity of AE-3763 in mice, the results of a preliminary study have shown no overt toxic effect even at the high dose of 300 mg/kg, iv[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8197 mL 9.0985 mL 18.1970 mL
5 mM 0.3639 mL 1.8197 mL 3.6394 mL
10 mM 0.1820 mL 0.9099 mL 1.8197 mL
*Please refer to the solubility information to select the appropriate solvent.
Animal Administration


D-Galactosamine shock is induced in C3H/HeN mice (6-7 w, 22-25 g). AE-3763 (10 or 100 mg/kg) is administrated intraperitoneally six times at 2 h interval. Control animals receive the vehicle (PBS) instead of AE-3763. Animal’s survival rate is observed up to 24 h after shock induction[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight







O=C(O)CN1CCN(CC(N[[email protected]](C(N2[[email protected]](C(N[[email protected]@H](C(C)C)C(C(F)(F)F)=O)=O)CCC2)=O)C(C)C)=O)C1=O


Please store the product under the recommended conditions in the Certificate of Analysis.


Room temperature in continental US; may vary elsewhere

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Cat. No.: HY-19406