2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. Mineralocorticoid Receptor
  4. Apararenone

Apararenone (MT-3995) is a novel non-steroidal mineralocorticoid receptor antagonists under development for the treatment of diabetic nephropathies and non-alcoholic steatohepatitis.

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Apararenone

Apararenone Estructura química

No. CAS : 945966-46-1

Tamaño Precio Stock Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in DMSO En stock
Solid
5 mg En stock
10 mg En stock
25 mg En stock
50 mg En stock
100 mg En stock
200 mg   Obtener un presupuesto  
500 mg   Obtener un presupuesto  

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Other Forms of Apararenone:

Apararenone Related Antibodies

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Descripciòn

Apararenone (MT-3995) is a novel non-steroidal mineralocorticoid receptor antagonists under development for the treatment of diabetic nephropathies and non-alcoholic steatohepatitis.

IC50 & Target

Mineralocorticoid receptor[1]
In Vivo

Recently, a phase II clinical trial has been initiated among patients with non-alcoholic steatohepatitis (NASH) in Japan[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Ensayo clínico
Peso molecular

364.39

Fòrmula

C17H17FN2O4S
No. CAS
Appearance

Solid

Color

White to off-white

SMILES

O=C1N(C2=CC=C(F)C=C2)C3=CC=C(NS(C)(=O)=O)C=C3OC1(C)C
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvente y solubilidad
In Vitro: 

DMSO : ≥ 125 mg/mL (343.04 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7443 mL 13.7216 mL 27.4431 mL
5 mM 0.5489 mL 2.7443 mL 5.4886 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7443 mL 13.7216 mL 27.4431 mL 68.6078 mL
5 mM 0.5489 mL 2.7443 mL 5.4886 mL 13.7216 mL
10 mM 0.2744 mL 1.3722 mL 2.7443 mL 6.8608 mL
15 mM 0.1830 mL 0.9148 mL 1.8295 mL 4.5739 mL
20 mM 0.1372 mL 0.6861 mL 1.3722 mL 3.4304 mL
25 mM 0.1098 mL 0.5489 mL 1.0977 mL 2.7443 mL
30 mM 0.0915 mL 0.4574 mL 0.9148 mL 2.2869 mL
40 mM 0.0686 mL 0.3430 mL 0.6861 mL 1.7152 mL
50 mM 0.0549 mL 0.2744 mL 0.5489 mL 1.3722 mL
60 mM 0.0457 mL 0.2287 mL 0.4574 mL 1.1435 mL
80 mM 0.0343 mL 0.1715 mL 0.3430 mL 0.8576 mL
100 mM 0.0274 mL 0.1372 mL 0.2744 mL 0.6861 mL
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Apararenone Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Apararenone945966-46-1MT-3995MT3995MT 3995Mineralocorticoid ReceptorInhibitorinhibitorinhibit

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Inquiry Information

Nombre del producto:
Apararenone
Cat. No.:
HY-109002
Cantidad:
MCE Japan Authorized Agent:

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