2. Metabolic Enzyme/Protease
  3. Phosphatase
  4. Calyculin A

Calyculin A  (Synonyms: (-)-Calyculin A; カリクリンA)

製品番号: HY-18983 純度: 98%
COA 取扱説明書 Technical Support

Calyculin A ((-)-Calyculin A) is a potent and cell-permeable protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) inhibitor with IC50s of 2 nM and 0.5-1 nM, respectively.

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Calyculin A

Calyculin A 構造式

CAS 番号 : 101932-71-2

容量 価格（税別） 在庫状況 数量
10 μg $1450 在庫あり

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Calyculin A 関連抗体

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製品説明

Calyculin A ((-)-Calyculin A) is a potent and cell-permeable protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) inhibitor with IC50s of 2 nM and 0.5-1 nM, respectively[1].

IC50 & Target

IC50: 2 nM (PP1); 0.5-1 nM (PP2A)[1]
体外実験

Calyculin A (1-10 nM; 24 hours) induces cytotoxicity in MG63 cells in a dose-dependent manner[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Calyculin A 関連抗体

Cell Cytotoxicity Assay[2]

Cell Line: Human osteosarcoma MG63 cells
Concentration: 0, 1, 2, 5, 10 nM
Incubation Time: 24 hours
Result: Treatment with 0.1 nM for 24 h had a minimal effect on MG63 cell survival. Cell rounding and shrinking were obvious in the cultures treated for 24 h with 5 nM. The level of the cell viability treated with 10 nM was 27% that of the control cultures.
分子量

1009.17

分子式

C50H81N4O15P
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O[C@@H]([C@H]([C@@H](N(C)C)COC)O)C(NCC[C@@H](C1=NC(/C=C/C[C@@H]([C@@H](C)[C@H](O)C2)O[C@@]32C(C)(C)[C@@H](OP(O)(O)=O)[C@@H]([C@@H](OC)C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C(C)/C(C)=C/C=C/C(C)=C\C#N)O3)=CO1)C)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
純度とドキュメンテーション

純度: 99.67%

COA (250 KB) RP-HPLC (135 KB)

取扱説明書 (2659 KB)
参考文献
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Calyculin A Related Classifications

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一般には略語で表示されます：C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Calyculin A101932-71-2(-)-Calyculin APhosphataseInhibitorinhibitorinhibit

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製品名:
Calyculin A
製品番号:
HY-18983
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