2. Cell Cycle/DNA Damage TGF-beta/Smad Stem Cell/Wnt Membrane Transporter/Ion Channel
  3. DNA/RNA Synthesis TGF-beta/Smad Proton Pump
  4. Chebulinic acid

Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity.

For research use only. We do not sell to patients.

CAS No. : 18942-26-2

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solid
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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of Chebulinic acid:

Chebulinic acid Related Antibodies

Top Publications Citing Use of Products
Cell Proliferation/Viability Assay
ELISA
RT-PCR
In Vivo Efficacy Study
WB

    Chebulinic acid purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2025 Sep 3.  [Abstract]

    Body weight changes in Female BALB/c mice aged 6–8 weeks after treatment with 20 mg/kg of Salvianolic acid A (SAA), Chebulinic Acid, Tannic acid, or Punicalagin via i.g. upon challenge once daily for 3 days. 300 mg/kg T-705 administered via i.g. was used as a positive control.

    Chebulinic acid purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2025 Sep 3.  [Abstract]

    T-705 and SAA significantly reduced viral copies in the liver in Female BALB/c mice aged 6–8 weeks after treatment with 20 mg/kg of Salvianolic acid A (SAA), Chebulinic Acid, Tannic acid, or Punicalagin via i.g. upon challenge once daily for 3 days. 300 mg/kg T-705 administered via i.g. was used as a positive control.

    Chebulinic acid purchased from MedChemExpress. Usage Cited in: Pharmaceutics. 2024 Jun 2;16(6):751.

    Chebulinic acid (0-50 μg/mL; 24, 48 h) showed no cytotoxicity towards A549 cells.

    Chebulinic acid purchased from MedChemExpress. Usage Cited in: Pharmaceutics. 2024 Jun 2;16(6):751.

    A549 cells were pre-treated with active compounds (Gallic acid, Chebulagic acid, and Chebulinic acid) (0–20 µg/mL) for 24 h. Then, the cells were exposed to CoV2-SP (100 ng/mL) for 3 h. The IL-6 (A), IL-1β (B), and IL-18 secretions (C) in the culture supernatant were examined by ELISA.

    Chebulinic acid purchased from MedChemExpress. Usage Cited in: Pharmaceutics. 2024 Jun 2;16(6):751.

    Inhibitory effects of active compounds (Gallic acid, Chebulagic acid and Chebulinic acid) on the IL-6 (A), IL-1β (B), IL-18 (C), and NLRP3 gene expressions (D) in CoV2-SP-induced A549 cells. A549 cells were pre-treated with active compounds (gallic acid, chebulagic acid and chebulinic acid) (0–20 µg/mL) for 24 h. Then, the cells were exposed to CoV2-SP (100 ng/mL) for 3 h. The mRNA expressions were determined using RT-qPCR.

    Chebulinic acid purchased from MedChemExpress. Usage Cited in: Pharmaceutics. 2024 Jun 2;16(6):751.

    The effects of Chebulagic acid and chebulinic acid inhibited the NLRP3 inflammasome pathway in CoV2-SP-induced A549 cells. A549 cells were pre-treated with chebulagic acid and Chebulinic acid (0–20 µg/mL) for 24 h. Then, the cells were exposed to CoV2-SP (100 ng/mL) for 3 h. The inhibitory effects of chebulagic acid and chebulinic acid on the expression of NLRP3, ASC, and pro-caspase-1 (p50) and cleaved-caspase-1 (p20) proteins in A549 cells are displayed in western blot.

    View All DNA/RNA Synthesis Isoform Specific Products:

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    RNASE L DNA Polymerases RNA Polymerases Helicases DNA Ligase

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    • Purity & Documentation

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    • Customer Review

    Description

    Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity.

    IC50 & Target

    target: M. tuberculosis DNA gyrase[1], SMAD-3 phosphorylation[2], H+ K+-ATPase activity.[3] IC50: 65.01 μg/ml ( H+ K+-ATPase ) [3]
    In Vitro

    In vitro: binding of Chebulinic acid causes displacement of catalytic Tyr129 away from its target DNA-phosphate molecule. [1] Chebulinic acid reduce the expression and activity of MMP-2 at an ED50 value of 100 μM. EMT (Epithelial to Mesenchymal Transition) is found to be induced in ARPE-19 cells, through SMAD-3 phosphorylation and it is inhibited by CA. [2] chebulinic acid significantly inhibited H+ K+-ATPase activity in vitrowith IC50 of 65.01 μg/ml. [3]

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Chebulinic acid Related Antibodies
    Molecular Weight

    956.68

    Formula

    C41H32O27
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    OC(C[C@H](C(O[C@@]([C@H](O[C@H]1OC(C2=CC(O)=C(O)C(O)=C2)=O)COC(C3=CC(O)=C(O)C(O)=C3)=O)([H])[C@@](OC(C4=CC(O)=C(O)C(O)=C4)=O)([H])[C@@]1([H])OC5=O)=O)[C@@]([C@H]6O)([H])C(C5=CC(O)=C7O)=C7OC6=O)=O
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (104.53 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.0453 mL 5.2264 mL 10.4528 mL
    5 mM 0.2091 mL 1.0453 mL 2.0906 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
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    Working solution concentration: mg/mL
    Purity & Documentation

    Purity: 99.68%

    SDS (393 KB)

    COA (270 KB) HNMR (331 KB) LCMS (93 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.0453 mL 5.2264 mL 10.4528 mL 26.1320 mL
    5 mM 0.2091 mL 1.0453 mL 2.0906 mL 5.2264 mL
    10 mM 0.1045 mL 0.5226 mL 1.0453 mL 2.6132 mL
    15 mM 0.0697 mL 0.3484 mL 0.6969 mL 1.7421 mL
    20 mM 0.0523 mL 0.2613 mL 0.5226 mL 1.3066 mL
    25 mM 0.0418 mL 0.2091 mL 0.4181 mL 1.0453 mL
    30 mM 0.0348 mL 0.1742 mL 0.3484 mL 0.8711 mL
    40 mM 0.0261 mL 0.1307 mL 0.2613 mL 0.6533 mL
    50 mM 0.0209 mL 0.1045 mL 0.2091 mL 0.5226 mL
    60 mM 0.0174 mL 0.0871 mL 0.1742 mL 0.4355 mL
    80 mM 0.0131 mL 0.0653 mL 0.1307 mL 0.3267 mL
    100 mM 0.0105 mL 0.0523 mL 0.1045 mL 0.2613 mL
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    Chebulinic acid Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Chebulinic acid18942-26-2DNA/RNA SynthesisTGF-beta/SmadProton PumpTransforming growth factor betaInhibitorinhibitorinhibit

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