1. Cell Cycle/DNA Damage TGF-beta/Smad Stem Cell/Wnt Membrane Transporter/Ion Channel
  2. DNA/RNA Synthesis TGF-beta/Smad Proton Pump
  3. Chebulinic acid

Chebulinic acid 

Cat. No.: HY-N2033 Purity: 99.42%
COA Handling Instructions

Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity.

For research use only. We do not sell to patients.

Chebulinic acid Chemical Structure

Chebulinic acid Chemical Structure

CAS No. : 18942-26-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 799 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 799 In-stock
1 mg USD 256 In-stock
5 mg USD 539 In-stock
10 mg USD 759 In-stock
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Chebulinic acid

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review


Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity.

IC50 & Target

target: M. tuberculosis DNA gyrase[1], SMAD-3 phosphorylation[2], H+ K+-ATPase activity.[3] IC50: 65.01 μg/ml ( H+ K+-ATPase ) [3]

In Vitro

In vitro: binding of Chebulinic acid causes displacement of catalytic Tyr129 away from its target DNA-phosphate molecule. [1] Chebulinic acid reduce the expression and activity of MMP-2 at an ED50 value of 100 μM. EMT (Epithelial to Mesenchymal Transition) is found to be induced in ARPE-19 cells, through SMAD-3 phosphorylation and it is inhibited by CA. [2] chebulinic acid significantly inhibited H+ K+-ATPase activity in vitrowith IC50 of 65.01 μg/ml. [3]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight








Structure Classification
Initial Source

Room temperature in continental US; may vary elsewhere.


4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (104.53 mM; ultrasonic and warming and heat to 60°C)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0453 mL 5.2264 mL 10.4528 mL
5 mM 0.2091 mL 1.0453 mL 2.0906 mL
10 mM 0.1045 mL 0.5226 mL 1.0453 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: 99.42%

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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