1. Cell Cycle/DNA Damage
    TGF-beta/Smad
    Stem Cell/Wnt
    Membrane Transporter/Ion Channel
  2. DNA/RNA Synthesis
    TGF-beta/Smad
    Proton Pump
  3. Chebulinic acid

Chebulinic acid 

Cat. No.: HY-N2033
Handling Instructions

Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity.

For research use only. We do not sell to patients.

Chebulinic acid Chemical Structure

Chebulinic acid Chemical Structure

CAS No. : 18942-26-2

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Description

Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity.

IC50 & Target

target: M. tuberculosis DNA gyrase[1], SMAD-3 phosphorylation[2], H+ K+-ATPase activity.[3] IC50: 65.01 μg/ml ( H+ K+-ATPase ) [3]

In Vitro

In vitro: binding of Chebulinic acid causes displacement of catalytic Tyr129 away from its target DNA-phosphate molecule. [1] Chebulinic acid reduce the expression and activity of MMP-2 at an ED50 value of 100 μM. EMT (Epithelial to Mesenchymal Transition) is found to be induced in ARPE-19 cells, through SMAD-3 phosphorylation and it is inhibited by CA. [2] chebulinic acid significantly inhibited H+ K+-ATPase activity in vitrowith IC50 of 65.01 μg/ml. [3]

Molecular Weight

956.68

Formula

C₄₁H₃₂O₂₇

CAS No.

18942-26-2

SMILES

OC(C[[email protected]](C(O[[email protected]@]([[email protected]](O[[email protected]]1OC(C2=CC(O)=C(O)C(O)=C2)=O)COC(C3=CC(O)=C(O)C(O)=C3)=O)([H])[[email protected]@](OC(C4=CC(O)=C(O)C(O)=C4)=O)([H])[[email protected]@]1([H])OC5=O)=O)[[email protected]@]([[email protected]]6O)([H])C(C5=CC(O)=C7O)=C7OC6=O)=O

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Chebulinic acid
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