1. GPCR/G Protein
  2. Guanylate Cyclase

Cinaciguat (Synonyms: BAY 58-2667)

Cat. No.: HY-14181 Purity: 99.40%
Handling Instructions

Cinaciguat is an activator of guanylate cyclase (sGC), and used for acute decompensated heart failure.

For research use only. We do not sell to patients.
Cinaciguat Chemical Structure

Cinaciguat Chemical Structure

CAS No. : 329773-35-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 224 In-stock
2 mg USD 120 In-stock
5 mg USD 180 In-stock
10 mg USD 300 In-stock
50 mg USD 1080 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Other Forms of Cinaciguat:

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References


Cinaciguat is an activator of guanylate cyclase (sGC), and used for acute decompensated heart failure.

In Vitro

Cinaciguat (10 μM) significantly enhances intracellular cGMP generation. Cinaciguat does not dose-dependent effects on cell contraction and calcium transients[2].

In Vivo

Cinaciguat (10 mg/kg/day, p.o.) treatment in diabetic rats does not influence blood glucose levels, but leads to attenuated water intake. Cinaciguat treatment alleviates diabetes mellitus related oxidative stress, protects against DM related alteration of the NO-sGC-cGMP-PKG signalling, and alleviates DM related myocardium hypertrophy and apoptosis[1]. Cinaciguat (1-10-100 nM) induces concentration-dependent relaxations in strips from both WT and apo-sGC mice, but does not have any effect on phasic activity induced by PGF in WT or apo-sGC strips[3].

Clinical Trial
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 1.7677 mL 8.8386 mL 17.6772 mL
5 mM 0.3535 mL 1.7677 mL 3.5354 mL
10 mM 0.1768 mL 0.8839 mL 1.7677 mL
Please refer to the solubility information to select the appropriate solvent.
Animal Administration

Cinaciguat is suspended in 0.5 % methylcellulose solution.

After confirmation of DM, rats are randomised into four groups: vehicle-treated control, cinaciguat-treated control, vehicle-treated diabetic and cinaciguat-treated diabetic groups. Animals are treated for 8 weeks with 0.5% methylcellulose vehicle or with the sGC activator cinaciguat in suspension p.o. (10 mg/kg/day), starting immeadiately after DM confirmation. Water bottles are filled every morning with the same amount of fresh tap water and daily water intake is measured. Animal cages are handled with care and are not moved after water bottle replacement to prevent spilling of water from the bottles. Body weight of the animals are recorded every 2 days and the dose of cinaciguat is adjusted accordingly. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight








Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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