1. MAPK/ERK Pathway
  2. JNK
  3. DB07268

DB07268 

Cat. No.: HY-15737 Purity: 99.49%
Handling Instructions

DB07268 is a potent and selective JNK1 inhibitor with an IC50 value of 9 nM.

For research use only. We do not sell to patients.

DB07268 Chemical Structure

DB07268 Chemical Structure

CAS No. : 929007-72-7

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 158 In-stock
Estimated Time of Arrival: December 31
5 mg USD 144 In-stock
Estimated Time of Arrival: December 31
10 mg USD 228 In-stock
Estimated Time of Arrival: December 31
50 mg USD 660 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1080 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

DB07268 is a potent and selective JNK1 inhibitor with an IC50 value of 9 nM.

IC50 & Target[1]

JNK1

9 nM (IC50)

CHK1

0.82 μM (IC50)

PAK4

5.5 μM (IC50)

AKT1

15 μM (IC50)

ERK2

25 μM (IC50)

In Vitro

DB07268 (Compound 2b) also inhibits CHK1, PAK4, AKT1, and ERK2 with IC50s of 0.82 μM, 5.5 μM, 15 μM, and 25 μM, respectively[1].

Molecular Weight

321.33

Formula

C₁₇H₁₅N₅O₂

CAS No.

929007-72-7

SMILES

O=C(N)C1=CC=CC=C1NC2=NC(NC3=CC=CC(O)=C3)=NC=C2

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 32 mg/mL (99.59 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1121 mL 15.5603 mL 31.1207 mL
5 mM 0.6224 mL 3.1121 mL 6.2241 mL
10 mM 0.3112 mL 1.5560 mL 3.1121 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.47 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (6.47 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.49%

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DB07268
Cat. No.:
HY-15737
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