1. MAPK/ERK Pathway
  2. JNK
  3. DB07268

DB07268 

Cat. No.: HY-15737 Purity: 99.92%
COA Handling Instructions

DB07268 is a potent and selective JNK1 inhibitor with an IC50 value of 9 nM.

For research use only. We do not sell to patients.

DB07268 Chemical Structure

DB07268 Chemical Structure

CAS No. : 929007-72-7

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 74 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 74 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 105 In-stock
Estimated Time of Arrival: December 31
10 mg USD 165 In-stock
Estimated Time of Arrival: December 31
50 mg USD 605 In-stock
Estimated Time of Arrival: December 31
100 mg USD 957 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 4 publication(s) in Google Scholar

Top Publications Citing Use of Products

    DB07268 purchased from MCE. Usage Cited in: Toxins. 2021 Mar 18;13(3):221.  [Abstract]

    The JNK1 inhibitor DB07268 reduces the combination-induced cell death significantly. Consistent with the reduction in apoptosis, a significantly decreased ROS level is detected by pretreatment with DB07268. Meanwhile, the activation of p53 and Bim induced by the combination is nearly reduced to control level.

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    Description

    DB07268 is a potent and selective JNK1 inhibitor with an IC50 value of 9 nM.

    IC50 & Target[1]

    JNK1

    9 nM (IC50)

    CHK1

    0.82 μM (IC50)

    PAK4

    5.5 μM (IC50)

    AKT1

    15 μM (IC50)

    ERK2

    25 μM (IC50)

    In Vitro

    DB07268 (Compound 2b) also inhibits CHK1, PAK4, AKT1, and ERK2 with IC50s of 0.82 μM, 5.5 μM, 15 μM, and 25 μM, respectively[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Molecular Weight

    321.33

    Formula

    C17H15N5O2

    CAS No.
    SMILES

    O=C(N)C1=CC=CC=C1NC2=NC(NC3=CC=CC(O)=C3)=NC=C2

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 32 mg/mL (99.59 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.1121 mL 15.5603 mL 31.1207 mL
    5 mM 0.6224 mL 3.1121 mL 6.2241 mL
    10 mM 0.3112 mL 1.5560 mL 3.1121 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.08 mg/mL (6.47 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.08 mg/mL (6.47 mM); Clear solution

    *All of the co-solvents are available by MCE.
    Purity & Documentation

    Purity: 99.92%

    References
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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Inquiry Information

    Product Name:
    DB07268
    Cat. No.:
    HY-15737
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